protein

Recombinant Human Neurocalcin Delta

MBS145262

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Neurocalcin Delta

[Neurocalcin Delta]

[NCALD Human; Neurocalcin Delta Recombinant Human; Rocalcin Delta; MGC33870; MGC74858; Neurocalcin-Delta]

[neurocalcin-delta; Neurocalcin-delta; neurocalcin-delta; neurocalcin delta]

[NCALD]

[NCALD; NCALD]

NCALD_HUMAN

E Coli

193

MGSSHHHHHH SSGLVPRGSH MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF

Greater than 90% as determined by SDS-PAGE.

The NCALD protein solution (0.5mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 100mM NaCl, 1mM DTT and 40% glycerol. Sterile Filtered clear solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: NCALD produced in E Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (1-193.a.a) and having a molecular mass of 24.4kDa. NCALD is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: NCALD belongs to the neuronal calcium sensor (NCS) family. NCALD is cytosolic at inactive calcium levels; but, high intracellular calcium levels induce a conformational transformation which exposes the myristoyl group, causing protein association with membranes and partial co-localization with the perinuclear trans-golgi network. NCALD protein is a regulator of signal transduction by G protein-coupled receptor.

98985783

NP_001035714.1

NM_001040624.1

P61601

22,245 Da

Activation Of Ca-permeable Kainate Receptor Pathway (161046); Activation Of Kainate Receptors Upon Glutamate Binding Pathway (161043); Ionotropic Activity Of Kainate Receptors Pathway (161044); Neuronal System Pathway (106513); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (106534); Transmission Across Chemical Synapses Pathway (106516)

This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

NCALD: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. Belongs to the recoverin family. Chromosomal Location of Human Ortholog: 8q22.2. Cellular Component: clathrin coat of trans-Golgi network vesicle; intracellular; cytosol. Molecular Function: tubulin binding; protein binding; clathrin binding; calcium ion binding; actin binding; alpha-tubulin binding. Biological Process: vesicle-mediated transport; synaptic transmission; regulation of systemic arterial blood pressure; calcium-mediated signaling

0.005 mg

140 USD

0.02 mg

205

1 mg

2665