Recombinant Human Adenylate Kinase 4 | MyBioSource MBS145168 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Adenylate Kinase 4

catalog :

MBS145168

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS145168

products type :

Recombinant Protein

products full name :

Recombinant Human Adenylate Kinase 4

products short name :

Adenylate Kinase 4

products name syn :

AK4 Human; Adenylate Kinase 4 Human Recombinant; Adenylate Kinase 4; AK3; Adenylate Kinase 3-like 1; AK3L1; ATP-AMP transphosphorylase; Adenylate Kinase 3; GTP:AMP phosphotransferase; mitochondrial adenylate kinase-3; AK3L2; MGC166959; EC 2.7.4.3

other names :

adenylate kinase 4, mitochondrial; Adenylate kinase 4, mitochondrial; adenylate kinase 4, mitochondrial; AK 4; AK4; ATP-AMP transphosphorylase; GTP:AMP phosphotransferase AK4, mitochondrial; adenylate kinase 3-like 1; adenylate kinase isoenzyme 4, mitochondrial; mitochondrial adenylate kinase-3; nucleoside-triphosphate-adenylate kinase; adenylate kinase 4; Adenylate kinase 3-like; GTP:AMP phosphotransferase AK4

products gene name :

AK4

other gene names :

AK4; AK4; AK3; AK 4; AK3L1; AK3L2;

uniprot entry name :

KAD4_HUMAN

host :

E Coli

sequence length :

223

sequence :

MGSSHHHHHH SSGLVPRGSH MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY

purity :

Greater than 90% as determined by SDS-PAGE.

form :

AK4 Human solution (1mg/1ml) containing 20mM Trsi HCL pH-8, 2mM DTT, 0.1M NaCl, and 10% glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

PROTEIN KINASES; Enzymes; Adenylate Kinase

products description :

Description: AK4 Human Recombinant produced in E Coli is a single, non-glycosylated,polypeptide chain containing 243 amino acids (1-223a.a.) and having a molecular mass of 27.4kDa. AK4 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography. Introduction: AK4 belongs to the adenylate kinase family of enzymes. AK4 protein is restricted to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide structures in a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Hereditary mutations which cause AK4 deficiencies in erythrocytes have been associated to hemolytic anemia.

ncbi gi num :

53832003

ncbi acc num :

NP_001005353.1

ncbi gb acc num :

NM_001005353.2

uniprot acc num :

P27144

ncbi mol weight :

25,268 Da

ncbi pathways :

Adenine Ribonucleotide Biosynthesis, IMP = ADP,ATP Pathway (618580); Adenine Ribonucleotide Biosynthesis, IMP = ADP,ATP Pathway (468242); Metabolic Pathways (132956); Purine Metabolism Pathway (82944); Purine Metabolism Pathway (307); Adenosine Ribonucleotides De Novo Biosynthesis Pathway (835389); Purine Nucleotides De Novo Biosynthesis Pathway (142277); Superpathway Of Purine Nucleotide Salvage (907942)

ncbi summary :

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

uniprot summary :

AK3L1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP. Belongs to the adenylate kinase family. Protein type: EC 2.7.4.10; Nucleotide Metabolism - purine; Kinase, other; EC 2.7.4.6; Mitochondrial. Chromosomal Location of Human Ortholog: 1p31.3. Cellular Component: mitochondrion; mitochondrial matrix. Molecular Function: GTP binding; nucleoside diphosphate kinase activity; adenylate kinase activity; nucleoside triphosphate adenylate kinase activity; ATP binding. Biological Process: ATP metabolic process; response to drug; nucleoside triphosphate biosynthetic process; ADP biosynthetic process; nucleoside diphosphate phosphorylation; brain development; liver development; AMP metabolic process; GTP metabolic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage