protein

Recombinant Human Atonal Homolog 1

MBS145153

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Atonal Homolog 1

Atonal Homolog 1

ATOH1 Human; Atonal Homolog 1 Human Recombinant; Atonal homolog 1 (Drosophila); Helix-loop-helix protein hATH-1; Class A basic helix-loop-helix protein 14; bHLHa14; HATH1; Math1

protein atonal homolog 1; Protein atonal homolog 1; protein atonal homolog 1; class A basic helix-loop-helix protein 14; helix-loop-helix protein hATH-1; atonal homolog 1 (Drosophila); Class A basic helix-loop-helix protein 14; bHLHa14; Helix-loop-helix protein hATH-1; hATH1

ATOH1

ATOH1; ATOH1; ATH1; HATH1; MATH-1; bHLHa14; ATH1; BHLHA14; bHLHa14; hATH1

ATOH1_HUMAN

E Coli

354

MKQRRLAANA RERRRMHGLN HAFDQLRNVI PSFNNDKKLS KYETLQMAQI YINALSELLQ TPSGGEQPPP PPASCKSDHH HLRTAASYEG GAGNATAAGA QQASGGSQRP TPPGSCRTRF SAPASAGGYS VQLDALHFST FEDSALTAMM AQKNLSPSLP GSILQPVQEE NSKTSPRSHR SDGEFSPHSH YSDSDEAS

Greater than 85% as determined by SDS-PAGE.

The ATOH1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA and BSA). Avoid multiple freeze-thaw cycels.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: ATOH1 Human Recombinant produced in E Coli is a single polypeptide chain containing 198 amino acids (158-354) and having a molecular mass of 21.3kDa.ATOH1 is purified by proprietary chromatographic techniques. Introduction: ATOH1 activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is entirely provoked by the negative regulator of neurogenesis HES1. ATOH1 takes part in the differentiation of divisions of neural cells by activating E box-dependent transcription.

4885075

NP_005163.1

NM_005172.1

Q92858

38,160 Da

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]

ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis. Protein type: DNA-binding; Transcription factor; Cell development/differentiation. Chromosomal Location of Human Ortholog: 4q22. Cellular Component: nucleus. Molecular Function: protein dimerization activity; chromatin DNA binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; axon guidance; inner ear morphogenesis; central nervous system development; auditory receptor cell fate determination; neuron migration; positive regulation of transcription from RNA polymerase II promoter; positive regulation of auditory receptor cell differentiation; auditory receptor cell fate specification; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of apoptosis

0.005 mg

140 USD

0.02 mg

205

1 mg

2665