protein

Recombinant Human MOB1, Mps One Binder Kinase Activator-Like 1B

MBS144971

0.005 mg

140 USD

Recombinant Protein

Recombinant Human MOB1, Mps One Binder Kinase Activator-Like 1B

[MOB1]

[MOBKL1B Human; MOB1, Mps One Binder Kinase Activator-Like 1B Human Recombinant; Mps one binder kinase activator-like 1B; Mob1 alpha; Mob1A; Mob1 homolog 1B; Protein Mob4B; MOBKL1B; C2orf6; MOB4B; MOBK1B; MOB1; MATS1; FLJ10788; FLJ11595]

[MOB kinase activator 1A; MOB kinase activator 1A; MOB kinase activator 1A; MOB1 Mps One Binder homolog A; MOB1, Mps One Binder kinase activator-like 1B; mob1 alpha; mob1 homolog 1B; mps one binder kinase activator-like 1B; MOB kinase activator 1A; Mob1 alpha; Mob1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B]

[MOBKL1B]

[MOB1A; MOB1A; MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B; C2orf6; MOB4B; MOBK1B; MOBKL1B; Mob1A]

MOB1A_HUMAN

E Coli

216

MGSSHHHHHH SSGLVPRGSH MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG EDLNEWIAVN TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LGSKDR

Greater than 95.0% as determined by SDS-PAGE.

The MOBKL1B solution (0.5 mg/ml) 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 30% glycerol. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; MOB1, Mps One Binder Kinase Activator

Description: MOBKL1B Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 236 amino acids (1-216 a.a.) and having a molecular mass of 27.2kDa. The MOBKL1B is purified by proprietary chromatographic techniques. Introduction: MOBKL1B is a member of the MOB1/phocein family. MOBKL1B stimulates the kinase activity of STK38 and STK38L. MOBKL1B also binds to and regulates downstream targets such as the NDR-family protein kinases and LATS1 kinase. Thus, MOBKL1B participates in cell cycle checkpoint control and tumor inhibition.

148747437

NP_060691.2

NM_018221.3

Q9H8S9

16,928 Da

Hippo Signaling Pathway (1084759); Hippo Signaling Pathway (1108222); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Signal Transduction Pathway (477114); Signaling By Hippo Pathway (576275)

MOB1A: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Belongs to the MOB1/phocein family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, regulatory subunit. Chromosomal Location of Human Ortholog: 2p13.1. Cellular Component: cytosol. Molecular Function: protein binding; metal ion binding

0.005 mg

140 USD

0.02 mg

205

1 mg

2665