Recombinant Human Microtubule-Associated Protein, RP/EB Family, Member 1 | MyBioSource MBS144970 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Microtubule-Associated Protein, RP/EB Family, Member 1

catalog :

MBS144970

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144970

products type :

Recombinant Protein

products full name :

Recombinant Human Microtubule-Associated Protein, RP/EB Family, Member 1

products short name :

[Microtubule-Associated]

products name syn :

[MAPRE1 Human; Microtubule-Associated Protein, RP/EB Family, Member 1 Human Recombinant; Microtubule-associated protein RP/EB family member 1; APC-binding protein EB1; End-binding protein 1; EB1; MAPRE1; MGC117374; MGC129946]

other names :

[microtubule-associated protein RP/EB family member 1; Microtubule-associated protein RP/EB family member 1; microtubule-associated protein RP/EB family member 1; APC-binding protein EB1; adenomatous polyposis coli-binding protein EB1; end-binding protein 1; microtubule-associated protein, RP/EB family, member 1; APC-binding protein EB1; End-binding protein 1; EB1]

products gene name :

[MAPRE1]

other gene names :

[MAPRE1; MAPRE1; EB1; EB1]

uniprot entry name :

MARE1_HUMAN

host :

Escherichia Coli

sequence length :

268

sequence :

MGSSHHHHHH SSGLVPRGSH MAVNVYSTSV TSDNLSRHDM LAWINESLQL NLTKIEQLCS GAAYCQFMDM LFPGSIALKK VKFQAKLEHE YIQNFKILQA GFKRMGVDKI IPVDKLVKGK FQDNFEFVQW FKKFFDANYD GKDYDPVAAR QGQETAVAPS LVAPALNKPK KPLTSSSAAP QRPISTQRTA AAPKAGPGVV RKNPGVGNGD DEAAELMQQV NVLKLTVEDL EKERDFYFGK LRNIELICQE NEGENDPVLQ RIVDILYATD EGFVIPDEGG PQEEQEEY

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

The MAPRE1 solution (0.5 mg/ml) 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 2mM DTT and 0.1M NaCl.

storage stability :

Store at 4°C if entire vial will be used with 2-4 weeks. Store, frozen at - 20°C for longer periods of time. For longer storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze/thaw cycles.

other info1 :

Physical Appearance: Sterile filtered colorless solution

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Microtubule-Associated Protein

products description :

Description: MAPRE1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 288 amino acids (1-268 a.a.) and having a molecular mass of 32.2kDa. The MAPRE1 is purified by proprietary chromatographic techniques. Introduction: MAPRE1 (EB1) is a member of the intermediate/early gene family. MAPRE1 was first identified by its binding to the APC protein, which is often mutated in familial and sporadic, forms of colorectal cancer. MAPRE1 localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, MAPRE1 is associated with the centrosomes and spindle microtubules. MAPRE1 is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes.

ncbi gi num :

6912494

ncbi acc num :

NP_036457.1

ncbi gb acc num :

NM_012325.2

uniprot acc num :

Q15691

ncbi mol weight :

29,999 Da

ncbi pathways :

Anchoring Of The Basal Body To The Plasma Membrane Pathway (1127503); Assembly Of The Primary Cilium Pathway (1127502); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Centrosome Maturation Pathway (105807); G2/M Transition Pathway (105801); Loss Of Nlp From Mitotic Centrosomes Pathway (105811); Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway (105810); M Phase Pathway (105812); Mitotic Anaphase Pathway (105818)

ncbi summary :

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

uniprot summary :

EB1: a microtubule-associated protein of the RP/EB family. Binds to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. Localizes to microtubules, especially the growing ends, in interphase cells. Associates with the centrosomes and spindle microtubules during mitosis. Also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. May be involved in the regulation of microtubule structures and chromosome stability. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 20q11.1-q11.23. Cellular Component: Golgi apparatus; centrosome; microtubule; cell projection membrane; cytoplasmic microtubule; cytoplasm; cortical microtubule cytoskeleton; spindle; cytosol. Molecular Function: protein C-terminus binding; microtubule plus-end binding; protein binding. Biological Process: mitosis; cell proliferation; cell division; organelle organization and biogenesis; negative regulation of microtubule polymerization; mitotic cell cycle; G2/M transition of mitotic cell cycle

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage