protein

Recombinant Human Glycoprotein-2

MBS144938

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Glycoprotein-2

Glycoprotein-2

GP2 Human; Glycoprotein-2 Human Recombinant; Glycoprotein 2 (zymogen granule membrane); Pancreatic zymogen granule membrane protein GP-2; ZAP75; DKFZp779K0533

pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein; Pancreatic secretory granule membrane major glycoprotein GP2; pancreatic secretory granule membrane major glycoprotein GP2; pancreatic zymogen granule membrane associated protein GP2; glycoprotein 2 (zymogen granule membrane); Pancreatic zymogen granule membrane protein GP-2; ZAP75

GP2

GP2; GP2; ZAP75

GP2_HUMAN

Sf9 Insect Cells

537

Greater than 80% as determined by SDS-PAGE.

GP2 solution is supplied in 16mM HEPES buffer pH-7.5, 80mM NaCl and 20% glycerol.

Coating Concentration: 0.5-0.9 ug/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: GP2 is a cDNA coding for the free form of the human pancreatic secretory granule membrane major glycoprotein / GP2 having a molecular mass of 54,909 Dalton (protein component excluding glycosylation; observed molecular weight approx. 68 kDa) pH 5.4. GP2 protein is fused to a deca-histidine purification tag. Introduction: Crohn's Disease (CD), which is very common in Caucasians, is an inflammatory bowel diseases (IBD). Mucosal inflammation in CD seems to arise when dysregulation of the immune system breaks the balance between tolerance to commensal microbiota or food-derived antigens and immunity to pathogens. The autoimmune mechanisms takes part in the development of CD, and exocrine pancreas autoantibodies (PAB) are disease-specific in CD patients. It was established not too long ago that glycoprotein 2 (GP2) is the major autoantigenic mark recognized by CD-specific PAB. Furthermore to IgG and IgM PAB isotypes, IgA pancreatic autoantibodies were also identified in CD patients. GP2 is an extremely glycosylated 78 kDa protein with N-linked carbohydrates. It is responsible for up to 40% of all zymogen granule (ZG) membrane proteins in pancreatic acinar cells and is linked to the ZG membrane via a glycosyl phosphoinositol (GPI) anchor.

119220569

NP_001007241.2

NM_001007240.2

P55259

43,039 Da

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GP2: 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 16p12. Cellular Component: apical plasma membrane. Molecular Function: antigen binding. Biological Process: antigen transcytosis by M cells in mucosal-associated lymphoid tissue

0.002 mg

140 USD

0.01 mg

205

1 mg

4345