Recombinant Human RAB7A, Member RAS Oncogene Family | MyBioSource MBS144887 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human RAB7A, Member RAS Oncogene Family

catalog :

MBS144887

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144887

products type :

Recombinant Protein

products full name :

Recombinant Human RAB7A, Member RAS Oncogene Family

products short name :

RAB7A

products name syn :

RAB7A Human; RAB7A, Member RAS Oncogene Family Human Recombinant; RAB7A member RAS oncogene family; RAB7; ras-related protein Rab-7a; FLJ20819; PSN; CMT2B; PRO2706

other names :

ras-related protein Rab-7a; Ras-related protein Rab-7a; ras-related protein Rab-7a; RAB7, member RAS oncogene family; Ras-associated protein RAB7; RAB7A, member RAS oncogene family

products gene name :

RAB7A

other gene names :

RAB7A; RAB7A; RAB7; PRO2706; RAB7

uniprot entry name :

RAB7A_HUMAN

host :

E Coli

sequence length :

207

purity :

Greater than 90% as determined by SDS-PAGE.

form :

The RAB7A protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)1mM DTT, 100mM NaCl and 30% glycerol. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Member RAS Oncogene Family

products description :

Description: RAB7A produced in E Coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (1-207a.a.) and having a molecular mass of 25.6kDa.RAB7A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: RAB7A belongs to the Ras superfamily of small Rab GTPases. RAB7A connects with the RIPL effector protein to regulator membrane trafficking from early to late endosome and to lysosomes. RAB7A can also regulate growth receptor endocytic trafficking, degradation, maturation of phagosome and autophagic vacuoles.

ncbi gi num :

34147513

ncbi acc num :

NP_004628.4

ncbi gb acc num :

NM_004637.5

uniprot acc num :

P51149

ncbi mol weight :

23,490 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Endocytosis Pathway (102279); Endocytosis Pathway (102181); IL12-mediated Signaling Events Pathway (137922); Immune System Pathway (106386); MHC Class II Antigen Presentation Pathway (645290); Phagosome Pathway (153910); Phagosome Pathway (153859)

ncbi summary :

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

uniprot summary :

Rab7: a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein. Chromosomal Location of Human Ortholog: 3q21.3. Cellular Component: Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; lysosomal membrane; retromer complex; lysosome; pre-autophagosomal structure membrane; vacuolar membrane; late endosome; melanosome; phagocytic vesicle. Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; Rac GTPase binding. Biological Process: protein transport; protein targeting to lysosome; early endosome to late endosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; endosome to lysosome transport; protein to membrane docking; endocytosis; Rab protein signal transduction; retrograde transport, endosome to Golgi; epidermal growth factor ligand processing; bone resorption. Disease: Charcot-marie-tooth Disease, Axonal, Type 2b

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage