catalog number :
MBS144843
products type :
Recombinant Protein
products full name :
Recombinant Human Family with Sequence Similarity 3, Member B
products short name :
[Family with Sequence Similarity 3]
products name syn :
[FAM3B Human; Family with Sequence Similarity 3, Member B Human Recombinant; Family with Sequence Similarity 3 member B; C21orf11; C21orf76; Cytokine-like protein 2-21; ORF9; PANDER; PRED44; Chromosome 21 open reading frame 11; Pancreatic-derived factor]
other names :
[protein FAM3B isoform a; Protein FAM3B; protein FAM3B; D21M16SJHU19e; cytokine-like protein 2-21; pancreatic derived factor; pancreatic-derived factor; family with sequence similarity 3, member B; Cytokine-like protein 2-21; Pancreatic-derived factor; PANDER]
products gene name :
[FAM3B]
other gene names :
[FAM3B; FAM3B; 2-21; ORF9; PANDER; PRED44; C21orf11; C21orf76; C21orf11; C21orf76; PANDER]
uniprot entry name :
FAM3B_HUMAN
sequence :
MKHHHHHH AS ELIPDAPLSS AAYSIRSIGE RPVLKAPVPK RQKCDHWTPC PSDTYAYRLL SGGGRSKYAK ICFEDNLLMG EQLGNVARGI NIAIVNYVTG NVTATRCFDM YEGDNSGPMT KFIQSAAPKS LLFMVTYDDG STRLNNDAKN AIEALGSKEI RNMKFRSSWV FIAAKGLELP SEIQREKINH SDAKNNRYSG WPAEIQIEGC IPKERS
purity :
Greater than 90% as determined by SDS-PAGE.
form :
FAM3B Human was filtered (0.4 um) and lyophilized from 0.5mg/ml supplied in 20mM TRIS, 50mM NaCl, pH 7.5
storage stability :
Store lyophilized FAM3B uman at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted FAM3B an be stored at 4°C for a limited period of time; it does not show any change after a week at 4°C.
other info1 :
Source: Escherichia Coli. Physical Appearance: Filtered White Lyophilized (Freeze-dried)powder).
other info2 :
Solubility: Add deionized water to prepare a working stock solution of 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Family with Sequence Similarity
products description :
Description: FAM3B Protein is a 24.1 kDa protein containing 216 amino acids fused to a 10 aa N-Terminal His-tag. Introduction: FAM3B Protein induces apoptosis of alpha and beta cells in a quantity and time dependent way. FAM3B exists in insulin secretory granules and is possibly co-secreted with insulin.
ncbi acc num :
NP_478066.3
ncbi gb acc num :
NM_058186.3
ncbi mol weight :
20,815 Da
uniprot summary :
FAM3B: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Present in insulin secretory granules and likely cosecreted with insulin. Belongs to the FAM3 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Cytokine; Nuclear envelope; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: extracellular space; extracellular region. Molecular Function: cytokine activity. Biological Process: insulin secretion; apoptosis