Recombinant Human Protein Phosphatase 1, Catalytic Subunit Gamma | MyBioSource MBS144687 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Protein Phosphatase 1, Catalytic Subunit Gamma

catalog :

MBS144687

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144687

products type :

Recombinant Protein

products full name :

Recombinant Human Protein Phosphatase 1, Catalytic Subunit Gamma

products short name :

Phosphatase 1

products name syn :

PPP1CC Human; Protein Phosphatase 1, Catalytic Subunit Gamma Human Recombinant; Protein phosphatase 1 catalytic subunit gamma isozyme/isoform; Protein phosphatase 1C catalytic subunit; serine/threonine phosphatase 1 gamma; serine/threonine-protein phosphatase PP1-gamma catalytic subunit; PP1gamma; PPP1G; EC 3.1.3.16

other names :

serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; serine/threonine-protein phosphatase PP1-gamma catalytic subunit; protein phosphatase 1, catalytic subunit, gamma isoform; protein phosphatase 1C catalytic subunit; serine/threonine phosphatase 1 gamma; protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase 1C catalytic subunit

products gene name :

PPP1CC

other gene names :

PPP1CC; PPP1CC; PP1C; PP-1G; PPP1G; PP-1G

uniprot entry name :

PP1G_HUMAN

host :

E Coli

sequence length :

337

purity :

Greater than 85% as determined by SDS-PAGE.

form :

The PPP1CC solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 50% glycerol. Sterile Filtered colorless solution.

products categories :

ENZYMES; Enzymes; Phosphatase

products description :

Description: PPP1CC Human Recombinant produced in E Coli is a single polypeptide chain containing 343 amino acids (1-323) and having a molecular mass of 39.1kDa.PPP1CC is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: PPP1CC is vital for cell division and takes part in the regulation of protein synthesis, muscle contractility and glycogen metabolism. Additionally, PPP1CC has a role in long-term synaptic plasticity and regulation of ionic conductance, and has a significant role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.

ncbi gi num :

350276247

ncbi acc num :

NP_001231903.1

ncbi gb acc num :

NM_001244974.1

uniprot acc num :

P36873

ncbi mol weight :

38,518 Da

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Aurora B Signaling Pathway (138080); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Disease Pathway (530764)

ncbi summary :

The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

uniprot summary :

PPP1CC: is a catalytic subunit of protein phosphatase 1 (PP1), a ubiquitous cytosolic serine-threonine phosphatase. Composed a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer s disease. Down-regulated in lung squamous cell carcinoma. Protein type: Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16. Chromosomal Location of Human Ortholog: 12q24.1-q24.2. Cellular Component: protein complex; focal adhesion; mitochondrion; cytoplasm; nucleolus; nuclear speck; midbody; cytosol; nucleus; cleavage furrow. Molecular Function: protein binding; metal ion binding; phosphoric monoester hydrolase activity; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; protein kinase binding. Biological Process: glycogen metabolic process; cell division; transforming growth factor beta receptor signaling pathway; triacylglycerol catabolic process; mitotic cell cycle; circadian regulation of gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of circadian rhythm; protein amino acid dephosphorylation; entrainment of circadian clock by photoperiod

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

0.1 mg

price3 :

1220

more info or order :

MyBioSource product webpage