Recombinant Human Linker for Activation of T Cells | MyBioSource MBS144636 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Linker for Activation of T Cells

catalog :

MBS144636

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144636

products type :

Recombinant Protein

products full name :

Recombinant Human Linker for Activation of T Cells

products short name :

Linker for Activation of T Cells

products name syn :

LAT Human; Linker for Activation of T Cells Human Recombinant; Linker for activation of T cells; LAT1; 36 kDa phospho-tyrosine adapter protein; p36-38; pp36; linker for activation of T cells transmembrane adaptor; linker for activation of T-cells family member 1

other names :

linker for activation of T-cells family member 1 isoform b; Linker for activation of T-cells family member 1; linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; linker for activation of T cells, transmembrane adaptor; p36-38; linker for activation of T cells; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38

products gene name :

LAT

other gene names :

LAT; LAT; LAT1; pp36; pp36

uniprot entry name :

LAT_HUMAN

host :

E Coli

sequence length :

233

purity :

Greater than 95% as determined by SDS-PAGE.

form :

The LAT solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 1mM DTT. Sterile Filtered colorless solution.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: LAT Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (28-233) and having a molecular mass of 24.4 kDa (Molecular weight on SDS-PAGE will appear higher).LAT is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: LAT is a vital membrane protein that is phosphorylated by ZAP-70/Syk protein tyrosine kinases succeeding activation of the T-cell antigen receptor (TCR) signal transduction pathway. LAT is expressed in T lymphocytes in interstitial spaces, platelets and megakaryocytes.

ncbi gi num :

62739155

ncbi acc num :

NP_001014987.1

ncbi gb acc num :

NM_001014987.1

uniprot acc num :

O43561

ncbi mol weight :

27,774 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); FCERI Mediated Ca+2 Mobilization Pathway (833827); FCERI Mediated MAPK Activation Pathway (833826); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493); Fc Epsilon Receptor (FCERI) Signaling Pathway (833825); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590)

ncbi summary :

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

LAT: an adaptor protein involved in T-cell antigen receptor (TCR) signal transduction pathway. Plays an important role downstream of protein tyrosine kinases. Essential for TCR-mediated Ras-Erk activation and calcium flux. Protein type: Adaptor/scaffold; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: signalosome; mast cell granule; plasma membrane; integral to membrane; immunological synapse; intercellular junction; lipid raft. Molecular Function: protein binding; SH3/SH2 adaptor activity; protein kinase binding. Biological Process: integrin-mediated signaling pathway; platelet activation; positive regulation of signal transduction; T cell activation; calcium-mediated signaling; mast cell degranulation; T cell receptor signaling pathway; Ras protein signal transduction; innate immune response; immune response; gene expression; inflammatory response; blood coagulation; lymphocyte homeostasis; regulation of T cell activation

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage