Recombinant Human Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3 | MyBioSource MBS144582 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3

catalog :

MBS144582

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144582

products type :

Recombinant Protein

products full name :

Recombinant Human Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3

products short name :

Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3

products name syn :

GNAI3 Human; Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3 Human Recombinant; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3; G(i) alpha-3; 87U6

other names :

guanine nucleotide-binding protein G(k) subunit alpha; Guanine nucleotide-binding protein G(k) subunit alpha; guanine nucleotide-binding protein G(k) subunit alpha; guanine nucleotide-binding protein G(k) subunit alpha; g(i) alpha-3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; G(i) alpha-3

products gene name :

GNAI3

other gene names :

GNAI3; GNAI3; 87U6; ARCND1

uniprot entry name :

GNAI3_HUMAN

host :

E Coli

sequence length :

354

purity :

Greater than 90% as determined by SDS-PAGE.

form :

The GNAI3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 2mM DTT and 20% glycerol. Sterile Filtered colorless solution.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Guanine Nucleotide Binding Protein

products description :

Description: GNAI3 Human Recombinant produced in E Coli is a single polypeptide chain containing 377 amino acids (1-354) and having a molecular mass of 43.0kDa.GNAI3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: GNAI3 is a member of the G-alpha family and G (i/o/t/z) subfamily which act as modulators or transducers in several transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K+ channels. The active GTP-bound form inhibits the connotation of RGS14 with centrosomes and is essential for the translocation of RGS14 from the cytoplasm to the plasma membrane. GNAI3 takes part in cell division and is known to cooperate with RIC8A, S1PR1, RGS5, RGS10, RGS12, RGS14, RGS16, RGS18, and RGS19.

ncbi gi num :

5729850

ncbi acc num :

NP_006487.1

ncbi gb acc num :

NM_006496.3

uniprot acc num :

P08754

ncbi mol weight :

40,532 Da

ncbi pathways :

ADP Signalling Through P2Y Purinoceptor 12 Pathway (161060); Activation Of GABAB Receptors Pathway (187181); Adenylate Cyclase Inhibitory Pathway (106500); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); CXCR3-mediated Signaling Events Pathway (138011)

ncbi summary :

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]

uniprot summary :

G-alpha i3: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric. Chromosomal Location of Human Ortholog: 1p13. Cellular Component: Golgi apparatus; centrosome; membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; lipid raft. Molecular Function: GTPase activity; protein domain specific binding; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding. Biological Process: vesicle fusion; G-protein signaling, coupled to cAMP nucleotide second messenger; synaptic transmission; platelet activation; cell division; transport; metabolic process; negative regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase inhibiting pathway; cell cycle; blood coagulation. Disease: Auriculocondylar Syndrome 1

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage