product summary
Loading...
company name :
MyBioSource
product type :
protein
product name :
Recombinant Human T-cell immunoreceptor with Ig and ITIM domains
catalog :
MBS1444441
quantity :
0.05 mg (E-Coli)
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1444441
products type :
Recombinant Protein
products full name :
Recombinant Human T-cell immunoreceptor with Ig and ITIM domains
products short name :
T-cell immunoreceptor with Ig and ITIM domains
products name syn :
V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3
other names :
T-cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3
products gene name :
TIGIT
other gene names :
TIGIT; TIGIT; VSIG9; VSTM3; WUCAM; VSIG9; VSTM3
uniprot entry name :
TIGIT_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
22-141, Fragment at the N-terminal, provide the complete extracellular domain.
sequence length :
141
sequence :
MMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWE
QQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLT
VNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARF
QIP
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Homo sapiens (Human)
products categories :
Immunology
products description :
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
products references :
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells." Yu X., Harden K., Gonzalez L.C., Francesco M., Chiang E., Irving B., Tom I., Ivelja S., Refino C.J., Clark H., Eaton D., Grogan J.L. Nat. Immunol. 10:48-57(2009)
ncbi gi num :
256600228
ncbi acc num :
NP_776160.2
ncbi gb acc num :
NM_173799.3
uniprot acc num :
Q495A1
ncbi mol weight :
18,432 Da
ncbi pathways :
Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480)
ncbi summary :
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
size1 :
0.05 mg (E-Coli)
price1 :
205 USD
size2 :
0.2 mg (E-Coli)
price2 :
520
size3 :
0.5 mg (E-Coli)
price3 :
850
size4 :
0.05 mg (Baculovirus)
price4 :
855
size5 :
0.05 mg (Mammalian-Cell)
price5 :
1080
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!