Recombinant Human Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase | MyBioSource MBS144311 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase

catalog :

MBS144311

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144311

products type :

Recombinant Protein

products full name :

Recombinant Human Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase

products short name :

Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase

products name syn :

AASDHPPT Human; Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase Human Recombinant; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; 4'-phosphopantetheinyl transferase; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; AASD-PPT; LYS5 ortholog; AASDHPPT; LYS2; LYS5; CGI-80; DKFZp566E2346

other names :

L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; 4'-phosphopantetheinyl transferase; LYS5 ortholog; alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; 4'-phosphopantetheinyl transferase; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; AASD-PPT; LYS5 ortholog

products gene name :

AASDHPPT

other gene names :

AASDHPPT; AASDHPPT; LYS2; LYS5; CGI-80; AASD-PPT; AASD-PPT

uniprot entry name :

ADPPT_HUMAN

host :

E Coli

sequence length :

309

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The AASDHPPT solution (1 mg/ml) contains 20mM Tris-HCl Buffer (pH 8.0), 1mM DTT and 10% Glycerol. Sterile Filtered colorless solution.

products categories :

ENZYMES; Enzymes; Transferase

products description :

Description: AASDHPPT Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 316 amino acids (14-309 a.a.) and having a molecular mass of 36.4kDa. The AASDHPPT is purified by proprietary chromatographic techniques. Introduction: AASDHPPT is a member of the P-Pant transferase superfamily. AASDHPPT catalyzes the post-translational modification of target proteins by phosphopantetheine and can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN (in vitro). AASDHPPT is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. AASDHPPT is found in the heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney. It's been suggested that defects in the human AASDHPPT gene result in pipecolic acidemia.

ncbi gi num :

20357568

ncbi acc num :

NP_056238.2

ncbi gb acc num :

NM_015423.2

uniprot acc num :

Q9NRN7

ncbi mol weight :

15,574 Da

ncbi pathways :

Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000); Defective BTD Causes Biotidinase Deficiency Pathway (906015); Defective CD320 Causes Methylmalonic Aciduria Pathway (906012); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (906001); Defective GIF Causes Intrinsic Factor Deficiency Pathway (906004); Defective HLCS Causes Multiple Carboxylase Deficiency Pathway (906014); Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway (906003); Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway (906010); Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway (906009); Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway (906005)

ncbi summary :

The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008]

uniprot summary :

AASDHPPT: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4 - phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. Belongs to the P-Pant transferase superfamily. AcpS family. Protein type: Amino Acid Metabolism - lysine degradation; EC 2.7.8.-; Amino Acid Metabolism - lysine biosynthesis; Transferase. Chromosomal Location of Human Ortholog: 11q22. Cellular Component: cytosol. Molecular Function: protein binding; phosphopantetheinyltransferase activity; magnesium ion binding. Biological Process: vitamin metabolic process; macromolecule biosynthetic process; pantothenate metabolic process; water-soluble vitamin metabolic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage