protein

Recombinant Human Dimethylarginine Dimethylaminohydrolase 1

MBS144288

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Dimethylarginine Dimethylaminohydrolase 1

Dimethylarginine Dimethylaminohydrolase 1

DDAH1 Human; Dimethylarginine Dimethylaminohydrolase 1 Human Recombinant; DDAH; DDAH-1; Dimethylargininase-1; dimethylargininase-1; Dimethylarginine Dimethylaminohydrolase 1

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 2; N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; DDAH-1; DDAHI; NG, NG-dimethylarginine dimethylaminohydrolase; dimethylargininase-1; epididymis secretory protein Li 16; dimethylarginine dimethylaminohydrolase 1; DDAHI; Dimethylargininase-1

DDAH1

DDAH1; DDAH1; DDAH; HEL-S-16; DDAH; DDAH-1; Dimethylarginine dimethylaminohydrolase 1

DDAH1_HUMAN

E Coli

182

MGSSHHHHHH SSGLVPRGSH MGSMAGLGHP AAFGRATHAV VRALPESLGQ HALRSAKGEE VDVARAERQH QLYVGVLGSK LGLQVVELPA DESLPDCVFV EDVAVVCEET ALITRPGAPS RRKEVDMMKE ALEKLQLNIV EMKDENATLD GGDVLFTGRE FFVGLSKRTN QRGAEILADT FKDYAVSTVP VADGLHLKSF CSMAGPNLIA IGSSESAQKA LKIMQQMSDH RYDKLTVPDD IAANCIYLNI PNKGHVLLHR TPEEYPESAK VYEKLKDHML IPVSMSELEK VDGLLTCCSV LINKKVDS

Greater than 95% as determined by SDS-PAGE.

The DDAH1 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 1mM DTT, 50mM NaCl and 10% glycerol. Sterile Filtered clear solution.

20ug/20ul

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

ENZYMES; Enzymes; Hydrolase

Description: DDAH1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285a.a.) and having a molecular mass of 33.5kDa.DDAH1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: Dimethylarginine dimethylaminohydrolase 1, is a part of the Dimethylarginine Dimethylaminohydrolase gene family. DDAH1 participates in nitric oxide generation by regulating cellular concentrations of methylarginines, that in turn inhibit nitric oxide synthase activity. Deficiency of DDAH1 results in ADMA (asymmetric dimethylarginine) increase and a decrease in cGMP generation.

197313763

NP_001127917.1

NM_001134445.1

O94760

20,189 Da

This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

DDAH1: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Belongs to the DDAH family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.5.3.18; Hydrolase. Chromosomal Location of Human Ortholog: 1p22. Cellular Component: mitochondrion. Molecular Function: amino acid binding; dimethylargininase activity; metal ion binding; catalytic activity. Biological Process: positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; citrulline metabolic process; regulation of systemic arterial blood pressure; arginine catabolic process; nitric oxide mediated signal transduction

0.005 mg

140 USD

0.02 mg

205

1 mg

2665