Recombinant Human ADP-Ribosylation Factor 6 | MyBioSource MBS144284 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human ADP-Ribosylation Factor 6

catalog :

MBS144284

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144284

products type :

Recombinant Protein

products full name :

Recombinant Human ADP-Ribosylation Factor 6

products short name :

ADP-Ribosylation Factor 6

products name syn :

ARF6 Human; ADP-Ribosylation Factor 6 Human Recombinant; ADP-ribosylation factor 6; ARF6; DKFZp564M0264

other names :

ADP-ribosylation factor 6; ADP-ribosylation factor 6; ADP-ribosylation factor 6; ADP-ribosylation factor 6

products gene name :

ARF6

other gene names :

ARF6; ARF6

uniprot entry name :

ARF6_HUMAN

host :

E Coli

sequence length :

175

sequence :

MGSSHHHHHH SSGLVPRGSH MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE TVTYKNVKFN VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR QELHRIINDR EMRDAIILIF ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY VQPSCATSGD GLYEGLTWLT SNYKS

purity :

Greater than 95% as determined by SDS-PAGE.

form :

The ARF6 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 0.2mM PMSF and 20% glycerol. Sterile Filtered clear solution.

concentration :

1 mg/1ml

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; ADP-Ribosylation Factor

products description :

Description: ARF6 produced in E Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (1-175a.a.) and having a molecular mass of 22.2kDa.ARF6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: ARF6 is a part of the ADP ribosylation factor family of GTP-binding proteins. ARF6 is restricted to the plasma membrane, and controls vesicular trafficking, remodeling of membrane lipids, and signaling pathways which lead to actin remodeling. Furthermore, ARF6 is a key player in conservation of organelle integrity, assembly of coat proteins and activation of phospholipase D.

ncbi gi num :

4502211

ncbi acc num :

NP_001654.1

ncbi gb acc num :

NM_001663.3

uniprot acc num :

P62330

ncbi mol weight :

20,082 Da

ncbi pathways :

Arf6 Downstream Pathway (138038); Arf6 Signaling Events Pathway (138034); Arf6 Trafficking Events Pathway (137954); Class I PI3K Signaling Events Pathway (138022); E-cadherin Signaling In The Nascent Adherens Junction Pathway (138005); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Insulin Signaling Pathway (198845)

ncbi summary :

This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]

uniprot summary :

ARF6: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development. Contributes to the regulation of dendritic branching and filopodia extension. Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24. Belongs to the small GTPase superfamily. Arf family. Protein type: G protein, monomeric, ARF; G protein, monomeric; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 14q21.3. Cellular Component: Golgi apparatus; ruffle; filopodium membrane; focal adhesion; membrane; endocytic vesicle; recycling endosome membrane; early endosome; plasma membrane; cell cortex; midbody; endosome; cleavage furrow. Molecular Function: GTPase activity; protein binding; GTP binding; thioesterase binding. Biological Process: myeloid cell apoptosis; metabolic process; regulation of filopodium formation; cell cycle; liver development; vesicle-mediated transport; regulation of Rac protein signal transduction; protein transport; positive regulation of actin filament polymerization; cell division; small GTPase mediated signal transduction; ruffle organization and biogenesis; negative regulation of receptor-mediated endocytosis; cortical actin cytoskeleton organization and biogenesis; cell adhesion; cell motility

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage