Recombinant Human V-crk Sarcoma Virus CT10 Oncogene | MyBioSource MBS144280 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human V-crk Sarcoma Virus CT10 Oncogene

catalog :

MBS144280

quantity :

0.001 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144280

products type :

Recombinant Protein

products full name :

Recombinant Human V-crk Sarcoma Virus CT10 Oncogene

products short name :

V-crk Sarcoma Virus CT10 Oncogene

products name syn :

CRK Human; V-crk Sarcoma Virus CT10 Oncogene Human Recombinant; Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK; CRKII

other names :

adapter molecule crk isoform b; Adapter molecule crk; adapter molecule crk; proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; Proto-oncogene c-Crk; p38

products gene name :

CRK

other gene names :

CRK; CRK; p38; CRKII

uniprot entry name :

CRK_HUMAN

host :

E Coli

sequence length :

204

sequence :

MGSSHHHHHH SSGLVPRGSH MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL IGGR.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The CRK solution (0.5 mg/ml) contains 20mM Tris-HCl Buffer (pH 8.0) and 10% Glycerol. Sterile Filtered colorless solution.

storage stability :

CRK should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; V-crk Sarcoma Virus CT10

products description :

Description: CRK Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 224 amino acids (1-204 a.a.) and having a molecular mass of 25kDa. The CRK is purified by proprietary chromatographic techniques. Introduction: CRK belongs to the signaling adapter protein family which binds to several tyrosine-phosphorylated proteins. CRK is involved in many cellular processes such as apoptosis, proliferation, and differentiation. CRK has a modular domain architecture consisting of an SH2 followed by two SH3 domains (src-homology domains). The N-terminal SH2 domain of the CRK protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.

ncbi gi num :

41327710

ncbi acc num :

NP_005197.3

ncbi gb acc num :

NM_005206.4

uniprot acc num :

P46108

ncbi mol weight :

22,906 Da

ncbi pathways :

ARMS-mediated Activation Pathway (106466); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); B Cell Receptor Signaling Pathway (198909); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528)

ncbi summary :

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex. Protein type: Adaptor/scaffold; Oncoprotein; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17p13.3. Cellular Component: cytoplasm; plasma membrane; nucleus; cytosol; actin cytoskeleton. Molecular Function: protein phosphorylated amino acid binding; protein binding; SH3/SH2 adaptor activity; ephrin receptor binding; SH2 domain binding. Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of Rac protein signal transduction; platelet activation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; insulin receptor signaling pathway; ephrin receptor signaling pathway; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway

size1 :

0.001 mg

price1 :

140 USD

size2 :

0.005 mg

price2 :

205

size3 :

0.05 mg

price3 :

1125

more info or order :

MyBioSource product webpage