catalog number :
MBS144267
products type :
Recombinant Protein
products full name :
Recombinant Human Protein Disulfide Isomerase A6
products short name :
Disulfide Isomerase A6
products name syn :
PDIA6 Human; Protein Disulfide Isomerase A6 Human Recombinant; Protein disulfide-isomerase A6; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7; PDIA6; ERP5; P5; TXNDC7
other names :
protein disulfide-isomerase A6 isoform a; Protein disulfide-isomerase A6; protein disulfide-isomerase A6; ER protein 5; endoplasmic reticulum protein 5; protein disulfide isomerase P5; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; thioredoxin domain containing 7 (protein disulfide isomerase); thioredoxin domain-containing protein 7; protein disulfide isomerase family A, member 6; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7
products gene name :
PDIA6
other gene names :
PDIA6; PDIA6; P5; ERP5; TXNDC7; ERP5; P5; TXNDC7; ER protein 5; ERp5
uniprot entry name :
PDIA6_HUMAN
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
The PDIA6 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 2mM DTT and 50mM NaCl. Sterile Filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
products categories :
ENZYMES; Enzymes; Isomerase
products description :
Description: PDIA6 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 442 amino acids (20-440 a.a.) and having a molecular mass of 48.5kDa. The PDIA6 is purified by proprietary chromatographic techniques. Introduction: PDIA6 belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes or periplasmic space of prokaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. PDIA6 functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6, also has a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
ncbi acc num :
NP_001269633.1
ncbi gb acc num :
NM_001282704.1
ncbi mol weight :
53,261 Da
ncbi pathways :
IRE1alpha Activates Chaperones Pathway 105906!!Metabolism Of Proteins Pathway 106230!!Protein Processing In Endoplasmic Reticulum Pathway 167325!!Protein Processing In Endoplasmic Reticulum Pathway 167190!!Unfolded Protein Response (UPR) Pathway 105904!!XBP1(S) Activates Chaperone Genes Pathway 530771
ncbi summary :
Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008]