Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase | MyBioSource MBS144259 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase

catalog :

MBS144259

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144259

products type :

Recombinant Protein

products full name :

Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase

products short name :

4-Hydroxyphenylpyruvate Dioxygenase

products name syn :

HPD Human; 4-Hydroxyphenylpyruvate Dioxygenase Human Recombinant; 4HPPD; GLOD3; 4-HPPD; PPD; HPPDase; Glyoxalase Domain Containing 3; 4-HydroxyphenylpYruvate Dioxygenase

other names :

4-hydroxyphenylpyruvate dioxygenase isoform 2; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; glyoxalase domain containing 3; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase

products gene name :

HPD

other gene names :

HPD; HPD; PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE; PPD; 4HPPD; HPD; HPPDase

uniprot entry name :

HPPD_HUMAN

host :

E Coli

sequence length :

354

purity :

Greater than 90% as determined by SDS-PAGE.

form :

The HPD protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 1mM DTT, 50mM NaCl and 20% glycerol. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Oxygenase

products description :

Description: HPD produced in E Coli is a single, non-glycosylated polypeptide chain containing 413 amino acids (1-393a.a.) and having a molecular mass of 47kDa.HPD is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: 4-Hydroxyphenylpyruvate Dioxygenase Isoform-1 is an Fe-containing enzyme, which catalyzes the second reaction in the catabolism of tyrosine the conversion of 4-hydroxyphenylpyruvate to homogentisate. Present as a homodimer, HPD uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Flaws in the gene encoding HPD result in tyrosinemia type 3 and hawkinsinuria, two inborn defects of metabolism which are related to a number of symptoms, like mental retardation and seizures and hair and urine abnormalities.

ncbi gi num :

285002264

ncbi acc num :

NP_001165464.1

ncbi gb acc num :

NM_001171993.1

uniprot acc num :

P32754

ncbi mol weight :

40,497 Da

ncbi pathways :

Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Phenylalanine And Tyrosine Catabolism Pathway (106189); Phenylalanine Metabolism Pathway (82960); Phenylalanine Metabolism Pathway (327); Tyrosine Degradation, Tyrosine = Homogentisate Pathway (522534); Tyrosine Degradation, Tyrosine = Homogentisate Pathway (468237); Tyrosine Metabolism Pathway (82959); Tyrosine Metabolism Pathway (325)

ncbi summary :

The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

uniprot summary :

HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Amino Acid Metabolism - tyrosine; Oxidoreductase; Amino Acid Metabolism - phenylalanine; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; EC 1.13.11.27. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: cytosol. Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding. Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process. Disease: Hawkinsinuria; Tyrosinemia, Type Iii

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage