protein

Recombinant Human Dynein Light Chain LC8 Type-1

MBS144235

0.02 mg

205 USD

Recombinant Protein

Recombinant Human Dynein Light Chain LC8 Type-1

Dynein Light Chain LC8 Type-1

DYNLL1 Human; Dynein Light Chain LC8 Type-1 Human Recombinant; PIN; DLC1; DLC8; DNCL1; DNCLC1; Dynein Light Chain LC8-type 1; Dynein Cytoplasmic Light polypeptide 1; Protein Inhibitor of Neuronal Nitric Oxide Synthase

dynein light chain 1, cytoplasmic; Dynein light chain 1, cytoplasmic; dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; dynein, cytoplasmic, light polypeptide 1; protein inhibitor of neuronal nitric oxide synthase; dynein, light chain, LC8-type 1; 8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; Protein inhibitor of neuronal nitric oxide synthase; PIN

DYNLL1

DYNLL1; DYNLL1; LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1; DLC1; DNCL1; DNCLC1; HDLC1; DLC8; PIN

DYL1_HUMAN

E Coli

89

MGSSHHHHHH SSGLVPRGSH MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG

Greater than 90% as determined by SDS-PAGE.

The DYNLL1 protein solution (1mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0) 0.2M NaCl, 1mM DTT and 10% glycerol. Sterile Filtered clear solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Dynein Light Chain

Description: DYNLL1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 109 amino acids (1-89a.a.) and having a molecular mass of 12.5kDa. The DYNLL1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: DYNLL1 is a protein that cooperates with NOS1 causing NOS1 inhibition. Binding of DYNLL1 weakens NOS1 (Neuronal nitric oxide synthase) dimer, a conformation needed for activity, and it regulates several biologic processes through its effects on nitric oxide synthase activity. DYNLL1 is a ubiquitously expressed protein that demonstrates high expression in testis and moderate expression in brain.

83267866

NP_001032583.1

NM_001037494.1

P63167

10,366 Da

Activation Of BH3-only Proteins Pathway 105658!!Activation Of BIM And Translocation To Mitochondria Pathway 105662!!Adaptive Immune System Pathway 366160!!Anchoring Of The Basal Body To The Plasma Membrane Pathway 1127503!!Apoptosis Pathway 105648!!Assembly Of The Primary Cilium Pathway 1127502!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Centrosome Maturation Pathway 105807!!G2/M Transition Pathway 105801

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

0.02 mg

205 USD