protein

Recombinant Human Rho GDP Dissociation Inhibitor (GDI) Alpha

MBS144194

0.02 mg

205 USD

Recombinant Protein

Recombinant Human Rho GDP Dissociation Inhibitor (GDI) Alpha

GDI

ARHGDIA Human; Rho GDP dissociation inhibitor (GDI) alpha Human Recombinant; Rho GDP-dissociation inhibitor 1; Rho GDI 1; Rho-GDI alpha; ARHGDIA; GDIA1; RHOGDI; RHOGDI-1; MGC117248

rho GDP-dissociation inhibitor 1 isoform a; Rho GDP-dissociation inhibitor 1; rho GDP-dissociation inhibitor 1; GDP-dissociation inhibitor, aplysia RAS-related 1; epididymis secretory sperm binding protein Li 47e; Rho GDP dissociation inhibitor (GDI) alpha; Rho-GDI alpha

ARHGDIA

ARHGDIA; ARHGDIA; GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e; GDIA1; Rho GDI 1

GDIR1_HUMAN

E Coli

204

Greater than 95.0% as determined by SDS-PAGE.

The ARHGDIA solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Rho GDP Dissociation Inhibitor

Description: ARHGDIA Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 202 amino acids (24-204 a.a.) and having a molecular mass of 22.9kDa. The ARHGDIA is purified by proprietary chromatographic techniques. Introduction: Rho GDP-dissociation inhibitor 1 (ARHGDIA) is a member of the RAS gene superfamily, which encodes small guanine nucleotide exchange (GTP/GDP) factors. ARHGDIA, which is localized to the cytoplasm, inhibits the dissociation of GDP from Rho proteins, thus preventing GTP from binding to and consequently activating Rho proteins. In humans, the ARHGDIA can be phosphorylated at Ser 101 by p21-activated kinase, an event that inhibits its activity and may result in positive feedback regulation of several ARHGDIA target proteins.

297374782

NP_001172006.1

NM_001185077.2

P52565

18,233 Da

Axonal Growth Inhibition (RHOA Activation) Pathway 106454!!Axonal Growth Stimulation Pathway 106453!!CDC42 Signaling Events Pathway 137994!!Neurotrophin Signaling Pathway 101143!!Neurotrophin Signaling Pathway 100064!!RAC1 Signaling Pathway 169355!!Regulation Of CDC42 Activity Pathway 137990!!Regulation Of RAC1 Activity Pathway 169346!!Regulation Of RhoA Activity Pathway 138070!!Rho GTPase Cycle Pathway 106503

This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

0.02 mg

205 USD