protein

Recombinant Human Acyl-CoA Thioesterase 13

MBS144185

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Acyl-CoA Thioesterase 13

Acyl-CoA Thioesterase 13

ACOT13 Human; Acyl-CoA Thioesterase 13 Human Recombinant; Acyl-coenzyme A thioesterase 13; Acyl-CoA thioesterase 13; Thioesterase superfamily member 2; ACOT13; THEM2; HT012; MGC4961; PNAS-27; ACOT13

acyl-coenzyme A thioesterase 13 isoform 2; Acyl-coenzyme A thioesterase 13; acyl-coenzyme A thioesterase 13; hypothalamus protein HT012; thioesterase superfamily member 2; acyl-CoA thioesterase 13; Thioesterase superfamily member 2Acyl-coenzyme A thioesterase 13, N-terminally processed

ACOT13

ACOT13; ACOT13; HT012; THEM2; PNAS-27; THEM2; Acyl-CoA thioesterase 13

ACO13_HUMAN

E Coli

117

MGSSHHHHHH SSGLVPRGSH MTSMTQSLRE VIKAMTKARN FERVLGKITL VSAAPGKVIC EMKVEEEHTN AIGTLHGGLT ATLVDNISTM ALLCTERGAP GVSVDMNITY MSPAKLGEDI VITAHVLKQG KTLAFTSVDL TNKATGKLIA QGRHTKHLGN.

Greater than 95.0% as determined by SDS-PAGE.

The ACOT13 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

ENZYMES; Enzymes; Esterase

Description: ACOT13 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 160 amino acids (1-140 a.a.) and having a molecular mass of 17.1kDa. The ACOT13 is purified by proprietary chromatographic techniques. Introduction: Acyl-coenzyme A thioesterase 13 (ACOT13) belongs to the thioesterase subfamily of esterase family. ACOT13 is highly expressed in the kidney with moderate expression in the brain, liver and intestines. ACOT13 contains a hotdog-fold and is thought to co-localize with microtubules, possibly having a role in cellular proliferation events. Deletion of a segment of the q arm of chromosome 6 is linked to early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus.

231567183

NP_001153566.1

NM_001160094.1

Q9NPJ3

12,366 Da

This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

THEM2: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro). Belongs to the thioesterase PaaI family. Protein type: EC 3.1.2.-. Chromosomal Location of Human Ortholog: 6p22.3. Cellular Component: mitochondrion; spindle; nucleus; cytosol. Molecular Function: acyl-CoA hydrolase activity. Biological Process: metabolic process; protein homotetramerization

0.002 mg

140 USD

0.01 mg

205

1 mg

5015