Recombinant Human Trefoil Factor-3 | MyBioSource MBS144182 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Trefoil Factor-3

catalog :

MBS144182

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144182

products type :

Recombinant Protein

products full name :

Recombinant Human Trefoil Factor-3

products short name :

Trefoil Factor-3

products name syn :

TFF3 Human; Trefoil Factor-3 Human Recombinant; TFF-3; ITF; TFI; HITF; hP1.B; TFF3; Trefoil factor 3; Intestinal trefoil factor

other names :

trefoil factor 3; Trefoil factor 3; trefoil factor 3; polypeptide P1.B; trefoil factor 3 (intestinal); Intestinal trefoil factor; hITF; Polypeptide P1.B; hP1.B

products gene name :

TFF3

other gene names :

TFF3; TFF3; ITF; P1B; TFI; ITF; TFI; hITF; hP1.B

uniprot entry name :

TFF3_HUMAN

host :

E Coli

sequence length :

sequence :

EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFKPLQEAECTF

purity :

Greater than 97.0% as determined by SDS-PAGE.

form :

Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized TFF3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TFF3 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized TFF3 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Determined by its ability to chemoattract human MCF-7 cells using a concentration 1.0-10.0 ng/ml.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Trefoil Factor

products description :

Description: TFF-3 Human Recombinant produced in E Coli is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 59 amino acid chains which includes a 40 amino acid trefoil motif containing 3 conserved interamolecular disulfide bonds and having a total molecular mass of 13.2kDa. TFF-3 Human Recombinant is purified by proprietary chromatographic techniques. Introduction: Proteins of the TFF family are characterized by obtaining a minimum of 1 copy of the trefoil motif, a 40-amino acid domain that contains 3 conserved disulfides. Trefoil Factors are stable secretory proteins expressed in gastrointestinal mucosa which protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium.TFF2 inhibits gastric acid motility & secretion. TFF2 stabilizes glycoproteins in the mucus gel through interactions with carbohydrate side chains. TFF3 induces ciliogenesis and promotes airway epithelial ciliated cell differentiation, relatively through an epidermal growth factor receptor-dependent pathway. TFF3 overexpression is crucial for progression in mouse and human hepatocellular carcinogenesis. TFF-3 is normally expressed in hepatocellular carcinoma and its expression associates with tumor grade.

ncbi gi num :

281485608

ncbi acc num :

NP_003217.3

ncbi gb acc num :

NM_003226.3

uniprot acc num :

Q07654

ncbi mol weight :

8,641 Da

ncbi pathways :

HIF-1-alpha Transcription Factor Network Pathway (138045); IL4-mediated Signaling Events Pathway (137933)

ncbi summary :

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

uniprot summary :

TFF3: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: proteinaceous extracellular matrix; extracellular region; secretory granule. Biological Process: response to peptide hormone stimulus; digestion; defense response

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage