protein

Recombinant Human 8-Oxoguanine DNA Glycosylase

MBS144159

1 mg

2665 USD

Recombinant Protein

Recombinant Human 8-Oxoguanine DNA Glycosylase

8-Oxoguanine DNA Glycosylase

OGG1 Human; 8-Oxoguanine DNA Glycosylase Human Recombinant; HMMH; HOGG1; MUTM; OGH1; AP lyase

N-glycosylase/DNA lyase isoform 1a; N-glycosylase/DNA lyase; N-glycosylase/DNA lyase; 8-hydroxyguanine DNA glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; OGG1 type 1f; 8-oxoguanine DNA glycosylase

OGG1

OGG1; OGG1; HMMH; MUTM; OGH1; HOGG1; MMH; MUTM; OGH1; AP lyase

OGG1_HUMAN

E Coli

345

MGSSHHHHHH SSGLVPRGSH TGSMPARALL PRRMGHRTLA STPALWASIP CPRSELRLDL VLPSGQSFRW REQSPAHWSG VLADQVWTLT QTEEQLHCTV YRGDKSQASR PTPDELEAVR KYFQLDVTLA QLYHHWGSVD SHFQEVAQKF QGVRLLRQDP IECLFSFICS SNNNIARITG MVERLCQAFG PRLIQLDDVT YHGFPSLQAL AGPEVEAHLR KLGLGYRARY VSASARAILE EQGGLAWLQQ LRESSYEEAH KALCILPGVG TKVADCICLM ALDKPQAVPV DVHMWHIAQRDYSWHPTTSQ AKGPSPQTNK ELGNFFRSLW GPYAGWAQAV LFSADLRQCR HAQEPPAKRRKGSKGPEG.

Greater than 90.0% as determined by SDS-PAGE.

0.5mg/ml solution containing 20mM Tris-HCl buffer pH-8, 0.1M NaCl and 40% Glycerol. Sterile filtered colorless solution.

ENZYMES; Enzymes; Glycosylase

Description: OGG1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 368 amino acids (1-345 a.a.) and having a molecular mass of 41.2 kDa. The OGG1 is fused to 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: OGG1 is a DNA glycosylase enzyme which takes part in base excision repair. OGG1 protein is the main enzyme accountable for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which arises as a result of exposure to reactive oxygen species (ROS). OGG1 shows beta lyase activity that nicks DNA 3'' to the lesion.

4505495

NP_002533.1

NM_002542.5

O15527

36,085 Da

Base Excision Repair Pathway 105838!!Base Excision Repair Pathway 83043!!Base Excision Repair Pathway 451!!Base-Excision Repair, AP Site Formation Pathway 105839!!Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway 105848!!Cleavage Of The Damaged Purine Pathway 105842!!DNA Repair Pathway 105837!!Depurination Pathway 105840!!Displacement Of DNA Glycosylase By APE1 Pathway 105849!!Recognition And Association Of DNA Glycosylase With Site Containing An Affected Purine Pathway 105841

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

1 mg

2665 USD