protein

Recombinant Human Fascin

MBS144155

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Fascin

Fascin

FSCN1 Human; Recombinant Human Fascin; Strongylocentrotus Purpuratus; actin-bundling protein; FAN1; HSN; SNL

fascin; Fascin; fascin; 55 kDa actin-bundling protein; fascin homolog 1, actin-bundling protein; singed-like (fascin homolog, sea urchin); fascin actin-bundling protein 1; 55 kDa actin-bundling protein; Singed-like protein; p55

FSCN1

FSCN1; FSCN1; HSN; SNL; p55; FAN1; FAN1; HSN; SNL

FSCN1_HUMAN

E Coli

493

Greater than 95.0% as determined by SDS-PAGE.

1mg/ml solution containing 20mM Tris pH-8, 2mM DTT, 0.1M NaCl & 20% glycerol. Sterile filtered colorless solution.

25ug/25ul.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: FSCN1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 513 amino acids (1-493 a.a.) and having a molecular mass of 56.7 kDa. The FSCN1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: FSCN1 is an actin-bundling protein that is responsible for rigidity to filopodial bundles to efficiently push the membrane forward during cytoskeleton remodeling and cell migration. FSCN1 takes part in the gathering of actin filament bundles present in microspikes, membrane ruffles, and stress fibers. FSCN1 is absent from most normal epithelia though is upregulated in multiple forms of human carcinoma, where its expression associates clinically with a poor prognosis. FSCN1 expression is abundantly found in neurons, glial cells, and endothelial cells.

4507115

NP_003079.1

NM_003088.3

Q96IH1

54,530 Da

MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928)

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Fascin: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Associates with beta-catenin. Ubiquitous. Belongs to the fascin family. Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding. Chromosomal Location of Human Ortholog: 7p22. Cellular Component: cytoplasm; stress fiber; cytosol; cell junction; actin cytoskeleton; filopodium. Molecular Function: protein binding, bridging; actin filament binding; protein binding; drug binding; actin binding. Biological Process: cell proliferation; actin filament bundle formation; cell migration; cell motility involved in cell locomotion; actin cytoskeleton organization and biogenesis

0.005 mg

140 USD

0.025 mg

205

1 mg

2665