Recombinant Human Protein cereblon (CRBN) | MyBioSource MBS1441437 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Protein cereblon (CRBN)

catalog :

MBS1441437

quantity :

0.05 mg (E-Coli)

price :

715 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1441437

products type :

Recombinant Protein

products full name :

Recombinant Human Protein cereblon (CRBN)

products short name :

Protein cereblon (CRBN)

products name syn :

Protein cereblon

other names :

protein cereblon isoform 2; Protein cereblon; protein cereblon; protein x 0001; cereblon

products gene name :

CRBN

products gene name syn :

CRBN; AD-006

other gene names :

CRBN; CRBN; MRT2; MRT2A; AD-006

uniprot entry name :

CRBN_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-442, Full length;

sequence length :

442

sequence :

MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSK
EAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSC
QVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKD
RTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVK
VKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMS
AVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHC
ANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSL
PSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCEL
DIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVN
PHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQ
CKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDT
EDEISPDKVILCL

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

ncbi gi num :

291045198

ncbi acc num :

NP_001166953.1

ncbi gb acc num :

NM_001173482.1

uniprot acc num :

Q96SW2

ncbi mol weight :

66kD

ncbi summary :

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

uniprot summary :

CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 3p26.2. Cellular Component: membrane; cytoplasm; nucleolus; nucleus. Molecular Function: protein binding; metal ion binding; ATP-dependent peptidase activity. Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; negative regulation of protein homooligomerization. Disease: Mental Retardation, Autosomal Recessive 2

size1 :

0.05 mg (E-Coli)

price1 :

715 USD

size2 :

0.05 mg (Baculovirus)

price2 :

715

size3 :

0.05 mg (Yeast)

price3 :

950

size4 :

0.1 mg (E-Coli)

price4 :

950

size5 :

0.1 mg (Baculovirus)

price5 :

990

more info or order :

MyBioSource product webpage