Recombinant Human Quinolinate Phosphoribosyltransferase | MyBioSource MBS144110 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Quinolinate Phosphoribosyltransferase

catalog :

MBS144110

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144110

products type :

Recombinant Protein

products full name :

Recombinant Human Quinolinate Phosphoribosyltransferase

products short name :

Quinolinate Phosphoribosyltransferase

products name syn :

QPRT Human; Quinolinate Phosphoribosyltransferase Human Recombinant; Quinolinate phosphoribosyltransferase; QPRTase; QAPRTase

other names :

nicotinate-nucleotide pyrophosphorylase; Nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; epididymis secretory sperm binding protein Li 90n; nicotinate-nucleotide pyrophosphorylase (carboxylating); quinolinate phosphoribosyltransferase; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase

products gene name :

QPRT

other gene names :

QPRT; QPRT; QPRTase; HEL-S-90n; QAPRTase; QPRTase

uniprot entry name :

NADC_HUMAN

host :

E Coli

sequence length :

297

sequence :

MGSSHHHHHH SSGLVPRGSH MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFALKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The QPRT solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol. Sterile Filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Transferase

products description :

Description: QPRT Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 317 amino acids (1-297 a.a.) and having a molecular mass of 32.9 kDa. The QPRT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: QPRT is a key enzyme in the catabolism of quinolinate. QPRT is in between the tryptophannicotinamide adenine dinucleotide (NAD) pathway, resulting in the production of nicotinic acid, carbon dioxide and pyrophosphate. Rise of QPRT levels in the brain is related to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington''s disease.

ncbi gi num :

45269149

ncbi acc num :

NP_055113.2

ncbi gb acc num :

NM_014298.3

uniprot acc num :

Q15274

ncbi mol weight :

30,846 Da

ncbi pathways :

Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000); Defective BTD Causes Biotidinase Deficiency Pathway (906015); Defective CD320 Causes Methylmalonic Aciduria Pathway (906012); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (906001); Defective GIF Causes Intrinsic Factor Deficiency Pathway (906004); Defective HLCS Causes Multiple Carboxylase Deficiency Pathway (906014); Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway (906003); Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway (906010); Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway (906009); Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway (906005)

ncbi summary :

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]

uniprot summary :

QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. Protein type: Transferase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.2.19. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: cytoplasm; cytosol. Molecular Function: protein homodimerization activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity. Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process; protein oligomerization

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage