Recombinant Human V-Ha-ras Harvey Rat Sarcoma Viral Oncogene Homolog | MyBioSource MBS144080 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human V-Ha-ras Harvey Rat Sarcoma Viral Oncogene Homolog

catalog :

MBS144080

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144080

products type :

Recombinant Protein

products full name :

Recombinant Human V-Ha-ras Harvey Rat Sarcoma Viral Oncogene Homolog

products short name :

V-Ha-ras Harvey Rat Sarcoma Viral Oncogene Homolog

products name syn :

HRAS Human; V-Ha-ras Harvey Rat Sarcoma Viral Oncogene Homolog Human Recombinant; C-BAS/HAS; C-H-RAS; C-HA-RAS1; CTLO; H-RASIDX; HAMSV; HRAS1; K-RAS; N-RAS; RASH1

other names :

GTPase HRas isoform 1; GTPase HRas; GTPase HRas; GTP- and GDP-binding peptide B; Ha-Ras1 proto-oncoprotein; Harvey rat sarcoma viral oncoprotein; Ras family small GTP binding protein H-Ras; c-has/bas p21 protein; c-ras-Ki-2 activated oncogene; p19 H-RasIDX protein; transformation gene: oncogene HAMSV; transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncogene homolog; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21rasGTPase HRas, N-terminally processed

products gene name :

HRAS

other gene names :

HRAS; HRAS; CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1; HRAS1

uniprot entry name :

RASH_HUMAN

host :

E Coli

sequence length :

189

purity :

Greater than 90% as determined by SDS-PAGE.

form :

0.5mg/ml solution containing 20mM Tris-HCl pH-8, 0.1M NaCl & 20% glycerol. Sterile filtered colorless solution.

concentration :

25ug/50ul

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: HRAS Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 194 amino acids (1-186 a.a.) and having a molecular mass of 22 kDa. HRAS protein is fused to an 8 amino acid His-Tag at C-terminus and purified by standard chromatography. Introduction: HRAS is part of the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes participate in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. HRAS go trough a continuous cycle of de- and re-palmitoylation, which mediates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in HRAS result in Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this HRAS gene are implicated in a range of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma.

ncbi gi num :

194363762

ncbi acc num :

NP_001123914.1

ncbi gb acc num :

NM_001130442.1

uniprot acc num :

P01112

ncbi mol weight :

18,870 Da

ncbi pathways :

ARMS-mediated Activation Pathway (106466); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Activation Of RAS In B Cells Pathway (576252); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Axon Guidance Pathway (83065); Axon Guidance Pathway (476)

ncbi summary :

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

HRas: a small GTPase protein of the Ras family. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Mutations are implicated in a variety of human tumors. Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, Ras; Oncoprotein; G protein. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: Golgi membrane; Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleus; cytosol. Molecular Function: protein C-terminus binding; protein binding; GTP binding. Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; activation of MAPKK activity; nerve growth factor receptor signaling pathway; protein heterooligomerization; positive regulation of JNK cascade; chemotaxis; signal transduction; synaptic transmission; positive regulation of MAP kinase activity; negative regulation of cell proliferation; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; small GTPase mediated signal transduction; positive regulation of cell proliferation; ephrin receptor signaling pathway; visual learning; negative regulation of neuron apoptosis; cell cycle arrest; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; mitotic cell cycle checkpoint; MAPKKK cascade; endocytosis; social behavior; regulation of synaptic transmission, GABAergic; positive regulation of Rac protein signal transduction; cell proliferation; organ morphogenesis; negative regulation of cell differentiation; Ras protein signal transduction; insulin receptor signaling pathway; striated muscle cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; blood coagulation; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis; leukocyte migration; positive regulation of epithelial cell proliferation; positive regulation of DNA replication; positive regulation of cell migration. Disease: Bladder Cancer; Thyroid Carcinoma, Follicular; Costello Syndrome; Schimmelpenning-feuerstein-mims Syndrome; Melanocytic Nevus Syndrome, Congenital; Nevus, Epidermal

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2220

more info or order :

MyBioSource product webpage