product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human UDP-Glucose Dehydrogenase
catalog :
MBS144078
quantity :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS144078
products type :
Recombinant Protein
products full name :
Recombinant Human UDP-Glucose Dehydrogenase
products short name :
UDP-Glucose Dehydrogenase
products name syn :
UGDH Human; UDP-Glucose Dehydrogenase Human Recombinant; GDH; UDP-GlcDH; UDPGDH; UGD; EC=1.1.1.22; UDP-Glc dehydrogenase; UDP-glucose 6-dehydrogenase; UGDH
other names :
UDP-glucose 6-dehydrogenase isoform 2; UDP-glucose 6-dehydrogenase; UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-glucose dehydrogenase; uridine diphospho-glucose dehydrogenase; UDP-glucose 6-dehydrogenase
products gene name :
UGDH
other gene names :
UGDH; UGDH; GDH; UGD; UDPGDH; UDP-GlcDH; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH
uniprot entry name :
UGDH_HUMAN
host :
E Coli
sequence length :
427
sequence :
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEM FEIKKICCIG AGYVGGPTCS VIAHMCPEIR VTVVDVNESR INAWNSPTLP IYEPGLKEVV ESCRGKNLFF STNIDDAIKE ADLVFISVNT PTKTYGMGKG RAADLKYIEA CARRIVQNSN GYKIVTEKST VPVRAAESIR RIFDANTKPN LNLQVLSNPE FLAEGTAIKD LKNPDRVLIG GDETPEGQRA VQALCAVYEH WVPREKILTT NTWSSELSKL AANAFLAQRI SSINSISALC EATGADVEEV ATAIGMDQRI GNKFLKASVG FGGSCFQKDV LNLVYLCEAL NLPEVARYWQ QVIDMNDYQR RRFASRIIDS LFNTVTDKKI AILGFAFKKD TGDTRESSSI YISKYLMDEG AHLHIYDPKV PREQIVVDLS HPGVSEDDQV SRLVTISKDP YEACDGAHAV VICTEWDMFK ELDYERIHKK MLKPAFIFDG RRVLDGLHNE LQTIGFQIET IGKKVSSKRI PYAPSGEIPK FSLQDPPNKK PKV.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
UGDH Human solution (0.5mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT, 1mM EDTA, 0.1M NaCl & 20% glycerol. Sterile filtered colorless solution.
products categories :
ENZYMES; Enzymes; Dehydrogenase
products description :
Description: UGDH Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 533 amino acids (1-494 a.a.) and having a molecular mass of 59.5 kDa. The UGDH is fused to 39 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: UGDH is part of the UDP-glucose/GDP-mannose dehydrogenase family and is a widely expressed enzyme localized in the liver. UGDH transfers UDP-glucose to UDP-glucuronate and thus takes part in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated products are ordinary molecules of the extracellular matrix and participate in signal transduction, cell migration, and cancer growth and metastasis.
ncbi gi num :
296040443
ncbi acc num :
NP_001171629.1
ncbi gb acc num :
NM_001184700.1
uniprot acc num :
O60701
ncbi mol weight :
44,415 Da
ncbi pathways :
Amino Sugar And Nucleotide Sugar Metabolism Pathway 82979!!Amino Sugar And Nucleotide Sugar Metabolism Pathway 350!!Ascorbate And Aldarate Metabolism Pathway 82932!!Ascorbate And Aldarate Metabolism Pathway 293!!Biological Oxidations Pathway 105698!!Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway 1127639!!Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway 1127658!!Defective GGT1 Causes Glutathionuria (GLUTH) Pathway 1127659!!Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway 1127660!!Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway 1127663
ncbi summary :
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
size :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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