protein

Recombinant Human Tumor Protein p53 Inducible Protein 3

MBS144072

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Tumor Protein p53 Inducible Protein 3

Tumor Protein p53 Inducible Protein 3

TP53I3 Human; Tumor Protein p53 Inducible Protein 3 Human Recombinant; TP53I3; PIG3; Quinone Oxidoreductase; tumor protein p53 inducible protein 3

quinone oxidoreductase PIG3 isoform 2; Quinone oxidoreductase PIG3; quinone oxidoreductase PIG3; p53-induced gene 3 protein; quinone oxidoreductase homolog; tumor protein p53 inducible protein 3; Tumor protein p53-inducible protein 3; p53-induced gene 3 protein

TP53I3

TP53I3; TP53I3; PIG3; PIG3

QORX_HUMAN

E Coli

248

Greater than 90% as determined by SDS-PAGE.

1mg/ml solution containing 20mM Tris HCl pH-8, 0.1M NaCl & 10% glycerol. Sterile filtered colorless solution.

TP53I3 Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

ENZYMES; Enzymes; Reductase

Description: TP53I3 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 352 amino acids (1-332 a.a.) and having a molecular mass of 37.6 kDa. TP53I3 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography. Introduction: TP53I3 participates in the generation of reactive oxygen species (ROS). TP53I3 has low NADPH-dependent naphtoquinone reductase activity, with a preference for 1,2-naphtoquinone over 1,4-naphtoquinone. TP53I3 has low NADPH-dependent diamine reductase activity (in vitro). TP53I3 is localized to the cytoplasm and induced in primary, non-transformed and transformed cell cultures after exposure to genotoxic agents. TP53I3 microsatellite polymorphism is associated with differential susceptibility to cancer.

332164791

NP_001193731.1

NM_001206802.2

Q53FA7

25,402 Da

Direct P53 Effectors Pathway (137939); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

TP53I3: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.-.-.-. Chromosomal Location of Human Ortholog: 2p23.3. Molecular Function: protein homodimerization activity; zinc ion binding; NADPH:quinone reductase activity; quinone binding. Biological Process: NADP metabolic process

0.005 mg

140 USD

0.025 mg

205

1 mg

2220