Recombinant Human Tissue Specific Transplantation Antigen P35B | MyBioSource MBS144067 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Tissue Specific Transplantation Antigen P35B

catalog :

MBS144067

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144067

products type :

Recombinant Protein

products full name :

Recombinant Human Tissue Specific Transplantation Antigen P35B

products short name :

Tissue Specific Transplantation Antigen P35B

products name syn :

TSTA3 Human; Tissue Specific Transplantation Antigen P35B Human Recombinant; FX; P35B; SDR4E1; GDP-L-fucose synthase; Protein FX

other names :

GDP-L-fucose synthase; GDP-L-fucose synthase; GDP-L-fucose synthase; 3-5 epimerase/4-reductase; GDP-4-keto-6-deoxy-D-mannose epimerase-reductase; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; red cell NADP(H)-binding protein; short chain dehydrogenase/reductase family 4E, member 1; tissue specific transplantation antigen 3; tissue specific transplantation antigen P35B; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; Protein FX; Red cell NADP(H)-binding protein; Short-chain dehydrogenase/reductase family 4E member 1

products gene name :

TSTA3

other gene names :

TSTA3; TSTA3; FX; P35B; SDR4E1; SDR4E1

uniprot entry name :

FCL_HUMAN

host :

E Coli

sequence length :

321

sequence :

MGSSHHHHHH SSGLVPRGSH MGEPQGSMRI LVTGGSGLVG KAIQKVVADG AGLPGEDWVF VSSKDADLTD TAQTRALFEK VQPTHVIHLA AMVGGLFRNI KYNLDFWRKN VHMNDNVLHS AFEVGARKVV SCLSTCIFPD KTTYPIDETM IHNGPPHNSN FGYSYAKRMI DVQNRAYFQQ YGCTFTAVIP TNVFGPHDNF NIEDGHVLPG LIHKVHLAKS SGSALTVWGT GNPRRQFIYS LDLAQLFIWV LREYNEVEPI ILSVGEEDEV SIKEAAEAVV EAMDFHGEVT FDTTKSDGQF KKTASNSKLR TYLPDFRFTP FKQAVKETCA WFTDNYEQAR K.

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

0.5mg/ml solution containing 20mM Tris pH-8, 2mM DTT, 50mM NaCl & 10% glycerol. Sterile filtered colorless solution.

storage stability :

TSTA3 Human although stable at 4C for 1 week, should be stored desiccated below -18C. Please prevent freeze thaw cycles.

products categories :

ENZYMES; Enzymes; Synthase

products description :

Description: TSTA3 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 341 amino acids (1-321 a.a.) and having a molecular mass of 38 kDa. The TSTA3 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: TSTA3 is a NADP(H)-binding protein. TSTA3 catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of numerous fucosyltransferases that take part in the expression of several glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in TSTA3 result in leukocyte adhesion deficiency, type II.

ncbi gi num :

4507709

ncbi acc num :

NP_003304.1

ncbi gb acc num :

NM_003313.3

uniprot acc num :

Q13630

ncbi mol weight :

35,893 Da

ncbi pathways :

Amino Sugar And Nucleotide Sugar Metabolism Pathway (82979); Amino Sugar And Nucleotide Sugar Metabolism Pathway (350); Fructose And Mannose Metabolism Pathway (82930); Fructose And Mannose Metabolism Pathway (291); GDP-L-fucose Biosynthesis I (from GDP-D-mannose) Pathway (142193); Metabolic Pathways (132956)

ncbi summary :

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

uniprot summary :

TSTA3: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Belongs to the fucose synthase family. Protein type: Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.271; Oxidoreductase; Carbohydrate Metabolism - amino sugar and nucleotide sugar. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: cytoplasm. Molecular Function: GDP-L-fucose synthase activity; electron carrier activity; isomerase activity; coenzyme binding; GDP-4-dehydro-D-rhamnose reductase activity. Biological Process: leukocyte adhesion; cytolysis; GDP-mannose metabolic process; de novo GDP-L-fucose biosynthetic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage