Recombinant Human Thioredoxin Reductase 1 | MyBioSource MBS144065 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Thioredoxin Reductase 1

catalog :

MBS144065

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144065

products type :

Recombinant Protein

products full name :

Recombinant Human Thioredoxin Reductase 1

products short name :

[Thioredoxin Reductase 1]

products name syn :

[TXNRD1 Human; Thioredoxin Reductase 1 Human Recombinant; Thioredoxin reductase 1 cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; TXNRD1; GRIM12; KDRF; TR1; TXNR; TRXR1; MGC9145]

other names :

[thioredoxin reductase 1, cytoplasmic isoform 3; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase 1, cytoplasmic; KM-102-derived reductase-like factor; gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; oxidoreductase; thioredoxin reductase GRIM-12; thioredoxin reductase TR1; thioredoxin reductase 1; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1]

products gene name :

[TXNRD1]

other gene names :

[TXNRD1; TXNRD1; TR; TR1; TXNR; TRXR1; GRIM-12; GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein]

uniprot entry name :

TRXR1_HUMAN

host :

E Coli

sequence length :

649

sequence :

MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQALQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLGIPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM VRSILLRGFD QDMANKIGEH MEEHGIKFIR QFVPIKVEQIEAGTPGRLRV VAQSTNSEEI IEGEYNTVML AIGRDACTRK IGLETVGVKI NEKTGKIPVT DEEQTNVPYI YAIGDILEDK VELTPVAIQAGRLLAQRLYA GSTVKCDYEN VPTTVFTPLE YGACGLSEEK AVEKFGEENI EVYHSYFWPL EWTIPSRDNN KCYAKIICNT KDNERVVGFH VLGPNAGEVT QGFAAALKCG LTKKQLDSTI GIHPVCAEVF TTLSVTKRSG ASILQAGC

purity :

Greater than 90% as determined by SDS-PAGE.

form :

0.5mg/ml solution containing 1xPBS pH-7.4 & 10% glycerol

storage stability :

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

other info1 :

Physical Appearance: Sterile filtered colorless solution.

other info2 :

Biological Activity: Specific activity is > 15 units/mg, and was measured in a coupled assay with 5,5'-Dithiobis(2-nitrobenzoic acid)(DTNB)and NADPH. The amount of TNB generated by NADPH was measured in absorbance at 412 nm.

products categories :

ENZYMES; Enzymes; Reductase

products description :

TXNRD1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 508 amino acids (161-647 a.a.) and having a molecular mass of 55.7 kDa. TXNRD1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

ncbi gi num :

148277071

ncbi acc num :

NP_001087240.1

ncbi gb acc num :

NM_001093771.2

uniprot acc num :

Q16881

ncbi pathways :

Cellular Responses To Stress Pathway (645258); Detoxification Of Reactive Oxygen Species Pathway (1127552); Disease Pathway (530764); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Nucleotides Pathway (106263); Oxidative Stress Pathway (198916); PPARA Activates Gene Expression Pathway (530749); Pyrimidine Metabolism Pathway (82946)

ncbi summary :

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity. Protein type: Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Nuclear receptor co-regulator; Oxidoreductase. Chromosomal Location of Human Ortholog: 12q23-q24.1. Cellular Component: nucleoplasm; nucleolus; cytosol. Molecular Function: protein binding; thioredoxin-disulfide reductase activity; electron carrier activity; FAD binding; protein disulfide oxidoreductase activity. Biological Process: response to reactive oxygen species; nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; nucleobase, nucleoside and nucleotide interconversion; cellular lipid metabolic process; signal transduction

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2235

more info or order :

MyBioSource product webpage