Recombinant Human Runt-Related Transcription Factor 3 | MyBioSource MBS144046 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Runt-Related Transcription Factor 3

catalog :

MBS144046

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144046

products type :

Recombinant Protein

products full name :

Recombinant Human Runt-Related Transcription Factor 3

products short name :

Runt-Related Transcription Factor 3

products name syn :

RUNX3 Human; Runt-Related Transcription Factor 3 Human Recombinant; AML2; CBFA3; PEBP2aC; PEBP2A3; FLJ34510; MGC16070; RUNX3; Oncogene AML-2; Runt-related transcription factor 3; Core-binding factor subunit alpha-3; Acute myeloid leukemia 2 protein; Polyomavirus enhancer-binding protein 2 alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit

other names :

runt-related transcription factor 3 isoform 1; Runt-related transcription factor 3; runt-related transcription factor 3; CBF-alpha-3; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; oncogene AML-2; polyomavirus enhancer-binding protein 2 alpha C subunit; transcription factor AML2; runt-related transcription factor 3; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; CBF-alpha-3; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEA2-alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit

products gene name :

RUNX3

other gene names :

RUNX3; RUNX3; AML2; CBFA3; PEBP2aC; AML2; CBFA3; PEBP2A3; CBF-alpha-3; PEA2-alpha C; PEBP2-alpha C

uniprot entry name :

RUNX3_HUMAN

host :

E Coli

sequence length :

429

sequence :

MGSSHHHHHH SSGLVPRGSH MRSMVDVLAD HAGELVRTDS PNFLCSVLPS HWRCNKTLPV AFKVVALGDV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ VARFNDLRFV GRSGRGKSFT LTITVFTNPT QVATYHRAIK VTVDGPREPR RHRQK.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

RUNX3 Human solution containing 20mM Tris HCL pH-8, 0.1M NaCl, & 20% glycerol. Sterile filtered colorless solution.

storage stability :

RUNX3 Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: RUNX3 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (53-186 a.a.) and having a molecular mass of 17.1 kDa. The RUNX3 is fused to 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: RUNX3 is part of the RUNX family that mediates the expression of genes which participate in cellular differentiation and cell cycle progression. RUNX3 heterodimer and the beta subunit form a complex that binds to the core DNA sequence 5''-PYGPYGGT-3'' found in several enhancers and promoters, and can either activate or suppress transcription. RUNX3 interacts with additional transcription factors. RUNX3 is a good candidate for gastric cancer tumor suppressor diagnosis.

ncbi gi num :

72534652

ncbi acc num :

NP_001026850.1

ncbi gb acc num :

NM_001031680.2

uniprot acc num :

Q13761

ncbi mol weight :

45,922 Da

ncbi pathways :

Endochondral Ossification Pathway (198812); SIDS Susceptibility Pathways (198901); TGF Beta Signaling Pathway (198810)

ncbi summary :

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

AML2: CBF binds to the core site, 5 -PYGPYGGT-3 , of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA- binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 1p36. Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; cytoplasm; nuclear chromatin; nucleolus; nucleus. Molecular Function: protein binding; transcription factor activity; ATP binding. Biological Process: peripheral nervous system neuron development; transcription from RNA polymerase II promoter; axon guidance; hair follicle morphogenesis; regulation of transcription, DNA-dependent; cell maturation; interferon-gamma production; chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; negative regulation of cell cycle; negative regulation of epithelial cell proliferation

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage