Recombinant Human RAB11A, Member RAS Oncogene Family | MyBioSource MBS144036 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human RAB11A, Member RAS Oncogene Family

catalog :

MBS144036

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144036

products type :

Recombinant Protein

products full name :

Recombinant Human RAB11A, Member RAS Oncogene Family

products short name :

RAB11A

products name syn :

RAB11A Human; RAB11A, Member RAS Oncogene Family Human Recombinant; RAB11; YL8; Ras-related protein Rab-11A; RAB11A

other names :

ras-related protein Rab-11A isoform 2; Ras-related protein Rab-11A; ras-related protein Rab-11A; RAB 11A, member oncogene family; rab-11; RAB11A, member RAS oncogene family; YL8

products gene name :

RAB11A

other gene names :

RAB11A; RAB11A; YL8; RAB11; Rab-11

uniprot entry name :

RB11A_HUMAN

host :

E Coli

sequence length :

155

purity :

Greater than 90% as determined by SDS-PAGE.

form :

RAB11A Human solution containing 20mM Tris-HCl pH-8, 1mM DTT, 1mM EDTA & 20% glycerol. Sterile filtered colorless solution.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Member RAS Oncogene Family

products description :

Description: RAB11A Human Recombinant produced in E Coli is a single, non-glycosylated,polypeptide chain containing 249 amino acids (1-213a.a.) and having a molecular mass of 28.1 kDa. RAB11A protein is fused to a 36 amino acid His tag at N-terminus and is purified by standard chromatography. Introduction: RAB11A is part of the small GTPase superfamily, Rab family. RAB11A is related with both constitutive and regulated secretory pathways, and takes part in protein transport. RAB11A is a well-known marker for protein trafficking, sorting, and recycling in the endosomal pathway. RAB11A is a main regulator of membrane delivery during cytokinesis.

ncbi gi num :

332205939

ncbi acc num :

NP_001193765.1

ncbi gb acc num :

NM_001206836.1

uniprot acc num :

P62491

ncbi mol weight :

17,659 Da

ncbi pathways :

Anchoring Of The Basal Body To The Plasma Membrane Pathway (1127503); Aquaporin-mediated Transport Pathway (187187); Arf6 Downstream Pathway (138038); Assembly Of The Primary Cilium Pathway (1127502); Cargo Trafficking To The Periciliary Membrane Pathway (1127504); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Membrane Trafficking Pathway (106160)

ncbi summary :

The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

uniprot summary :

RAB11A: Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3. Interacts with EXOC6 in a GTP- dependent manner. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SPE39//C14orf133. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. Belongs to the small GTPase superfamily. Rab family. Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, Rab; G protein. Chromosomal Location of Human Ortholog: 15q22.31. Cellular Component: Golgi apparatus; spindle pole; protein complex; cytoplasmic vesicle membrane; mitochondrion; recycling endosome membrane; trans-Golgi network; phagocytic vesicle; cytosol; kinetochore microtubule; multivesicular body; phagocytic vesicle membrane; recycling endosome; transport vesicle; perinuclear region of cytoplasm; axon; plasma membrane; cytoplasmic vesicle; vesicle; cleavage furrow. Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; syntaxin binding; microtubule binding; myosin V binding. Biological Process: regulation of long-term neuronal synaptic plasticity; establishment of vesicle localization; exocytosis; metabolic process; water transport; organelle organization and biogenesis; positive regulation of axon extension; cytokinesis; melanosome transport; mitotic metaphase plate congression; regulation of protein transport; vesicle-mediated transport; intracellular protein transport; astral microtubule organization and biogenesis; renal water homeostasis; plasma membrane to endosome transport; Rab protein signal transduction; transmembrane transport; neurite development

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2220

more info or order :

MyBioSource product webpage