Recombinant Human Phosphogluconate Dehydrogenase | MyBioSource MBS144031 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Phosphogluconate Dehydrogenase

catalog :

MBS144031

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144031

products type :

Recombinant Protein

products full name :

Recombinant Human Phosphogluconate Dehydrogenase

products short name :

Phosphogluconate Dehydrogenase

products name syn :

PGD Human; Phosphogluconate Dehydrogenase Human Recombinant; EC 1.1.1.44; 6PGD; PGDH; 6-phosphogluconate dehydrogenase decarboxylating; PGD

other names :

6-phosphogluconate dehydrogenase, decarboxylating isoform 1; 6-phosphogluconate dehydrogenase, decarboxylating; 6-phosphogluconate dehydrogenase, decarboxylating; phosphogluconate dehydrogenase

products gene name :

PGD

other gene names :

PGD; PGD; 6PGD; PGDH

uniprot entry name :

6PGD_HUMAN

host :

E Coli

sequence length :

483

sequence :

MGSSHHHHHH SSGLVPRGSH MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS YNA.

purity :

Greater than 95% as determined by SDS-PAGE.

form :

The PGD solution contains 20mM Tris-HCl pH-8, 1mM DTT, 0.1M NaCl and 10% glycerol. Sterile Filtered clear colorless solution.

concentration :

25ug/25ul

storage stability :

PGD Recombinant Human although stable at 4 degree C for 30 days, should be stored desiccated below -20 degree C for periods greater than 30 days. Please avoid freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Dehydrogenase

products description :

Description: PGD Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 503 amino acids (1-483 a.a.) and having a molecular mass of 55.3 kDa. The PGD is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: 6PGD is the second dehydrogenase in the pentose phosphate shunt. Pentose is neccesary for nucleic acid biosynthesis. The pentose phosphate cycle is a major source of NADPH 6PGD deficiency is usually asymptomatic, and the inheritance of this disorder is autosomal dominant. PGD deficiency raises the erythrocyte pyruvate kinase levels of activity and decreases glutathione synthetase, resulting in hemolysis.

ncbi gi num :

40068518

ncbi acc num :

NP_002622.2

ncbi gb acc num :

NM_002631.3

uniprot acc num :

P52209

ncbi mol weight :

51,872 Da

ncbi pathways :

Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Disease Pathway (530764); Glutathione Metabolism Pathway (82973); Glutathione Metabolism Pathway (343); Glycogen Storage Diseases Pathway (1127581); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Carbohydrates Pathway (106196); Myoclonic Epilepsy Of Lafora Pathway (1127582)

ncbi summary :

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

uniprot summary :

PGD: an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways. Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.44; Oxidoreductase; Other Amino Acids Metabolism - glutathione. Chromosomal Location of Human Ortholog: 1p36.22. Cellular Component: cytosol; nucleus. Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity; NADP binding. Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; carbohydrate metabolic process; pathogenesis; D-gluconate metabolic process; pentose biosynthetic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2220

more info or order :

MyBioSource product webpage