Recombinant Human Melanoma Antigen Family A, 4 | MyBioSource MBS144015 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Melanoma Antigen Family A, 4

catalog :

MBS144015

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS144015

products type :

Recombinant Protein

products full name :

Recombinant Human Melanoma Antigen Family A, 4

products short name :

[Melanoma Antigen Family A]

products name syn :

[CT1.4, MAGE4, MAGE-4 antigen, MAGE-X2 antigen, MAGE-41 antigen, MAGE4B, MGC21336, Cancer/testis antigen 1.4, MAGEA4.]

other names :

[melanoma-associated antigen 4; Melanoma-associated antigen 4; melanoma-associated antigen 4; MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen; cancer/testis antigen 1.4; cancer/testis antigen family 1, member 4; melanoma antigen family A, 4; melanoma antigen family A4; Cancer/testis antigen 1.4; CT1.4; MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen]

products gene name :

[MAGEA4]

other gene names :

[MAGEA4; MAGEA4; CT1.4; MAGE4; MAGE4A; MAGE4B; MAGE-41; MAGE-X2; MAGE4; CT1.4]

uniprot entry name :

MAGA4_HUMAN

host :

Escherichia Coli

sequence :

MGSSHHHHHH SSGLVPRGSH MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT LEEVPAAESA GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP DAESLFREAL SNKVDELAHF LLRKYRAKEL VTKAEMLERV IKNYKRCFPV IFGKASESLK MIFGIDVKEV DPTSNTYTLV TCLGLSYDGL LGNNQIFPKT GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY GEPRKLLTQD WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI AYPSLREAAL LEEEEGV

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

MAGEA4 Human solution containing 20mM Tris-HCl pH-8 & 20% glycerol.

concentration :

1mg/ml

storage stability :

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

other info2 :

Physical Appearance: Sterile filtered colorless solution.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Melanoma Antigen Family A

products description :

Description: MAGEA4 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 337 amino acids (1-317 a.a.) and having a molecular mass of 37 kDa. The MAGEA4 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: MAGEA4 is part of the MAGEA family, which directs the expression of tumor antigens that are identified on a human melanoma by autologous cytolytic T lymphocytes (CTL). MAGEA4 participates in embryonal development and tumor transformation or aspects of tumor progression. MAGEA4 is expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.

ncbi gi num :

58530867

ncbi acc num :

NP_001011548.1

ncbi gb acc num :

NM_001011548.1

uniprot acc num :

P43358

ncbi summary :

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

MAGE-A4: a member of the MAGE (melanoma-associated antigen) family of Cancer-Testis Antigens (CTAs). May play a role in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovary cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. The MAGE family of proteins, encompassing 12 highly homologous genes clustered at Xq26-28, are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. MAGE proteins are characterized by the presence of a conserved domain (MHD, MAGE Homology Domain). MAGE-A4 expression is high in ovarian serous carcinoma, various squamous carcinomas, testicular germ cell tumors, oesophageal mucosal melanoma, and triple-negative breast cancers. Spontaneous humoral and cellular immune responses against MAGE-A4 have been detected in cancer patients. MAGE family proteins bind to and activate RING E3 ubiquitin ligases. Protein type: Cancer Testis Antigen (CTA). Chromosomal Location of Human Ortholog: Xq28. Molecular Function: protein binding

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2235

more info or order :

MyBioSource product webpage