protein

Recombinant Human Nicotinamide Nucleotide Adenylyltransferase 2

MBS144009

0.01 mg

205 USD

Recombinant Protein

Recombinant Human Nicotinamide Nucleotide Adenylyltransferase 2

Nicotinamide Nucleotide Adenylyltransferase 2

NMNAT2 Human; Nicotinamide Nucleotide Adenylyltransferase 2 Human Recombinant; Nicotinamide Nucleotide Adenylyltransferase 2; C1orf15; Nicotinate-Nucleotide Adenylyltransferase 2; NaMN Adenylyltransferase 2; NMN Adenylyltransferase 2; PNAT2; KIAA0479; Chromosome 1 Open Reading Frame 15; Nicotinamide Mononucleotide Adenylyltransferase 2; Pyridine Nucleotide Adenylyltransferase 2; EC 2.7.7.1; EC 2.7.7.18

nicotinamide mononucleotide adenylyltransferase 2 isoform 1; Nicotinamide mononucleotide adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NaMN adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 2; pyridine nucleotide adenylyltransferase 2; nicotinamide nucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2 (EC:2.7.7.18); NaMN adenylyltransferase 2

NMNAT2

NMNAT2; NMNAT2; PNAT2; C1orf15; C1orf15; KIAA0479; NMN adenylyltransferase 2; NaMN adenylyltransferase 2

NMNA2_HUMAN

E Coli

307

Greater than 85.0% as determined by SDS-PAGE.

NMNAT2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. Sterile Filtered clear solution.

Biological Activity: Specific activity: > 500 pmol/min/ug. One unit will convert 1.0 pmole of beta-NADH per minute to beta-NAD at PH 8.0 at 37 degree C.

ENZYMES; Enzymes; Transferase

Description: NMNAT2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 327 amino acids (1-307 a.a) and having a molecular mass of 36.6kDa.NMNAT2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: Nicotinamide Nucleotide Adenylyltransferase 2, also known as NMNAT2 is a member of the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze a vital step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; NMNAT2 is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for NMNAT2. Among the diseases associated with NMNAT2 are tauopathy, and systemic lupus erythematosus.

24307989

NP_055854.1

NM_015039.3

Q9BZQ4

34,015 Da

Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway 906000!!Defective BTD Causes Biotidinase Deficiency Pathway 906015!!Defective CD320 Causes Methylmalonic Aciduria Pathway 906012!!Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway 906001!!Defective GIF Causes Intrinsic Factor Deficiency Pathway 906004!!Defective HLCS Causes Multiple Carboxylase Deficiency Pathway 906014!!Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway 906003!!Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway 906010!!Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway 906009!!Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway 906005

This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.01 mg

205 USD