Recombinant Human Glutamine Synthetase | MyBioSource MBS143992 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Glutamine Synthetase

catalog :

MBS143992

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143992

products type :

Recombinant Protein

products full name :

Recombinant Human Glutamine Synthetase

products short name :

Glutamine Synthetase

products name syn :

GLUL Human; Glutamine Synthetase Human Recombinant; GLNS; EC 6.3.1.2; EC 4.1.1.15; GLUL; Glutamine Synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase; PIG43; PIG59

other names :

glutamine synthetase; Glutamine synthetase; glutamine synthetase; cell proliferation-inducing protein 59; glutamate decarboxylase; glutamine synthase; proliferation-inducing protein 43; glutamate-ammonia ligase; Glutamate decarboxylase (EC:4.1.1.15); Glutamate--ammonia ligase

products gene name :

GLUL

other gene names :

GLUL; GLUL; GS; GLNS; PIG43; PIG59; GLNS; GS

uniprot entry name :

GLNA_HUMAN

host :

E Coli

sequence length :

373

sequence :

MGSSHHHHHH SSGLVPRGSH MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS VTEALIRTCL LNETGDEPFQ YKN.

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

GLUL Human solution containing 20mM Tris-HCl pH-8, 5mM DTT, 0.2M NaCl & 20% glycerol. Sterile filtered colorless solution.

products categories :

ENZYMES; Enzymes; Synthetase

products description :

Description: GLUL Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 393 amino acids (1-373 a.a.) and having a molecular mass of 44.2 kDa. The GLUL is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: GLUL catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a major source of energy and that takes part in cell proliferation, inhibition of apoptosis, and cell signaling. GLUL is expressed during early fetal stages, and has a role in maintaining body pH by removing ammonia from circulation. Mutations in GLUL gene are related with congenital glutamine deficiency.

ncbi gi num :

74271837

ncbi acc num :

NP_001028216.1

ncbi gb acc num :

NM_001033044.3

uniprot acc num :

P15104

ncbi mol weight :

42,064 Da

ncbi pathways :

Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway (106533); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); GABA Shunt Pathway (142350); GABAergic Synapse Pathway (377263)

ncbi summary :

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

uniprot summary :

GLUL: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner. Essential for proliferation of fetal skin fibroblasts. Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD). CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Belongs to the glutamine synthetase family. Protein type: Energy Metabolism - nitrogen; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 6.3.1.2; Amino Acid Metabolism - arginine and proline; Ligase; EC 4.1.1.15. Chromosomal Location of Human Ortholog: 1q31. Cellular Component: protein complex; mitochondrion; rough endoplasmic reticulum; cytoplasm; perikaryon; nerve terminal; nucleus; cytosol. Molecular Function: glutamate-ammonia ligase activity; identical protein binding; dynein light chain binding; glutamate binding; glutamate decarboxylase activity; manganese ion binding; magnesium ion binding; ATP binding. Biological Process: cell proliferation; glutamate catabolic process; synaptic transmission; glutamine biosynthetic process; response to glucose stimulus; positive regulation of insulin secretion; neurotransmitter uptake; amino acid biosynthetic process; cellular response to starvation; positive regulation of synaptic transmission, glutamatergic; positive regulation of epithelial cell proliferation; protein homooligomerization. Disease: Glutamine Deficiency, Congenital

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage