catalog number :
MBS143982
products type :
Recombinant Protein
products full name :
Recombinant Human Fission-1
products short name :
Fission-1
products name syn :
FIS1 Human; Fission-1 Human Recombinant; TTC11; Tetratricopeptide repeat domain 11; Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
other names :
mitochondrial fission 1 protein; Mitochondrial fission 1 protein; mitochondrial fission 1 protein; FIS1 homolog; H_NH0132A01.6; TPR repeat protein 11; hFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11
products gene name :
FIS1
other gene names :
FIS1; FIS1; TTC11; CGI-135; TTC11; hFis1; TPR repeat protein 11
uniprot entry name :
FIS1_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK DG.
purity :
Greater than 95% as determined by SDS-PAGE.
form :
FIS1 protein solution (1mg/ml) containing 20mM Tris-HCl pH-8 and 10% glycerol. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: FIS1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 142 amino acids (1-122 a.a.) and having a molecular mass of 16.3 kDa. FIS1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography. Introduction: FIS1 is part of the mitochondrial complex that promotes mitochondrial fission. FIS1 induces cytochrome C discharge from the mitochondrion to the cytosol, eventually leading to apoptosis. FIS1 participates in peroxisomal growth and division. The C terminus is required for mitochondrial localisation, while the N teminus is necessary for mitochondrial fission.
ncbi acc num :
NP_057152.2
ncbi gb acc num :
NM_016068.2
ncbi mol weight :
16,938 Da
ncbi summary :
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]