product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Endothelial Differentiation-Related Factor 1
catalog :
MBS143978
quantity :
0.005 mg
price :
140 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143978
products type :
Recombinant Protein
products full name :
Recombinant Human Endothelial Differentiation-Related Factor 1
products short name :
Endothelial Differentiation-Related Factor 1
products name syn :
EDF1 Human; Endothelial Differentiation-Related Factor 1 Human Recombinant; EDF-1; MBF1; Multiprotein-bridging factor 1
other names :
endothelial differentiation-related factor 1 isoform 3; Endothelial differentiation-related factor 1; endothelial differentiation-related factor 1; multiprotein bridging factor 1; endothelial differentiation-related factor 1; Multiprotein-bridging factor 1; MBF1
products gene name :
EDF1
other gene names :
EDF1; EDF1; MBF1; EDF-1; EDF-1; MBF1
uniprot entry name :
EDF1_HUMAN
host :
E Coli
sequence length :
141
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
0.5 mg/ml solution containing 20mM Tris pH-8, 1mM DTT, 0.1M NaCl & 20% glycerol. Sterile filtered colorless solution.
storage stability :
EDF1 Human although stable at 4C for 1 week, should be stored desiccated below -18C. Please prevent freeze thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: EDF1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (1-148 a.a.) and having a molecular mass of 17.4 kDa. The EDF1 is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques. Introduction: EDF1 controls endothelial cell differentiation. EDF1 has a role as a bridging protein that interconnects regulatory proteins and the basal transcriptional machinery, thus modulating the transcription of genes that take part in endothelial differentiation. EDF1 binds calmodulin through its IQ domain and controls nitric oxide synthase activity via calmodulin sequestration in the cytoplasm. EDF1 is localized in adult liver, heart, adipose tissues, intestine and pancreas.
ncbi gi num :
526253086
ncbi acc num :
NP_001268226.1
ncbi gb acc num :
NM_001281297.1
uniprot acc num :
O60869
ncbi mol weight :
15,636 Da
ncbi summary :
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
uniprot summary :
EDF1: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. 2 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 9q34.3. Cellular Component: transcription factor TFIID complex; cytoplasm; nucleolus; intracellular; nucleus. Molecular Function: calmodulin binding; methyltransferase activity; protein binding; histone acetyltransferase activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity. Biological Process: endothelial cell differentiation; regulation of lipid metabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of DNA binding
size1 :
0.005 mg
price1 :
140 USD
size2 :
0.025 mg
price2 :
205
size3 :
1 mg
price3 :
2665
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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