catalog number :
MBS143977
products type :
Recombinant Protein
products full name :
Recombinant Human Dynein Light Chain Roadblock-Type 1
products short name :
Dynein Light Chain Roadblock-Type 1
products name syn :
DYNLRB1 Human; Dynein Light Chain Roadblock-Type 1 Human Recombinant; BITH; BLP; DNCL2A; DNLC2A; ROBLD1; HSPC162
other names :
dynein light chain roadblock-type 1 isoform b; Dynein light chain roadblock-type 1; dynein light chain roadblock-type 1; ROBL/LC7-like 1; bithoraxoid-like protein; dynein, cytoplasmic, light polypeptide 2A; dynein-associated protein Km23; roadblock domain-containing protein 1; dynein, light chain, roadblock-type 1; Bithoraxoid-like protein; BLP; Dynein light chain 2A, cytoplasmic; Dynein-associated protein Km23; Roadblock domain-containing protein 1
products gene name :
DYNLRB1
other gene names :
DYNLRB1; DYNLRB1; BLP; BITH; DNCL2A; DNLC2A; ROBLD1; BITH; DNCL2A; DNLC2A; ROBLD1; BLP
uniprot entry name :
DLRB1_HUMAN
sequence :
MAEVEETLKR LQSQKGVQGI IVVNTEGIPI KSTMDNPTTT QYASLMHSFI LKARSTVRDI DPQNDLTFLR IRSKKNEIMV APDKDYFLIVIQNPTELEHH HHHH.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
1mg/ml solution containing 20mM Tris pH-8, & 10% glycerol. Sterile filtered colorless solution.
storage stability :
DYNLRB1 Human although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Dynein Light Chain
products description :
Description: DYNLRB1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 104 amino acids (1-96 a.a.) and having a molecular mass of 11.9 kDa. The DYNLRB1 is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques. Introduction: Dynein light chain roadblock-type (DYNLRB1) belongs to the roadblock dynein light chain family and encodes a cytoplasmic protein which is capable of binding intermediate chain proteins. Upregulation of the DYNLRB1 gene is linked with hepatocellular carcinomas, suggesting that DYNLRB1 may be involved in tumor progression.
ncbi acc num :
NP_001268656.1
ncbi gb acc num :
NM_001281727.1
ncbi mol weight :
5,060 Da
ncbi pathways :
Assembly Of The Primary Cilium Pathway 1127502!!Intraflagellar Transport Pathway 1127509!!Organelle Biogenesis And Maintenance Pathway 1127494!!TGF-beta Receptor Signaling Pathway 138024
ncbi summary :
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]