catalog number :
MBS143971
products type :
Recombinant Protein
products full name :
Recombinant Human D-Dopachrome Tautomerase
products short name :
D-Dopachrome Tautomerase
products name syn :
DDT Human; D-Dopachrome Tautomerase Human Recombinant; EC 4.1.1.84; DDCT; D-dopachtome decarboxylase; D-Dopachrome Tautomerase
other names :
D-dopachrome decarboxylase; D-dopachrome decarboxylase; D-dopachrome decarboxylase; phenylpyruvate tautomerase II; D-dopachrome tautomerase; D-dopachrome tautomerase; Phenylpyruvate tautomerase II
other gene names :
DDT; DDT; DDCT
uniprot entry name :
DOPD_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRILIRF FPLESWQIGK IGTVMTFL.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
DDT Human solution containing 20mM Tris HCL pH-8, & 10% glycerol. Sterile filtered colorless solution.
storage stability :
DDT Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
products categories :
ENZYMES; Enzymes
products description :
Description: DDT Recombinant E Coli produced in E Coli is a single, non-glycosylated polypeptide chain containing 138 amino acids (1-118 a.a.) and having a molecular mass of 14.8 kDa. The DDT is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: DDT is an enzyme that catayzes the tautomerization of D-dopachrome to give 5,6-dihydroxyindole (DHI). DDT is part of the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. DDT shares a homologous amino acid sequence (33% identical) with MIF and has similar tautomerase activity. DDT functions a proinflammatory cytokine.
ncbi acc num :
NP_001077861.1
ncbi gb acc num :
NM_001084392.1
ncbi mol weight :
11,323 Da
ncbi summary :
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]