product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Chloride Intracellular Channel 1
catalog :
MBS143959
quantity :
0.005 mg
price :
140 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143959
products type :
Recombinant Protein
products full name :
Recombinant Human Chloride Intracellular Channel 1
products short name :
Chloride Intracellular Channel 1
products name syn :
CLIC1 Human; Chloride Intracellular Channel 1 Human Recombinant; ACBP; ACBD1; CCK-RP; EP; CLIC1; G6; NCC27; Nuclear chloride ion channel 27; Chloride channel ABP; Regulatory nuclear chloride ion channel protein; hRNCC; Chloride intracellular channel protein 1
other names :
chloride intracellular channel protein 1; Chloride intracellular channel protein 1; chloride intracellular channel protein 1; RNCC protein; chloride channel ABP; hRNCC; nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64CLCP; regulatory nuclear chloride ion channel protein; chloride intracellular channel 1; Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC
products gene name :
CLIC1
other gene names :
CLIC1; CLIC1; G6; NCC27; G6; NCC27; NCC27; hRNCC
uniprot entry name :
CLIC1_HUMAN
host :
E Coli
sequence length :
241
sequence :
GSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
purity :
Greater than 90% as determined by SDS-PAGE.
form :
1mg/ml solution containing 20mM Tris-HCl pH-8, 0.1M NaCl & 10% glycerol. Sterile filtered colorless solution.
concentration :
1mg/ml
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Chloride Intracellular Channel
products description :
Description: CLIC1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 261amino acids (1-241a.a.) and having a molecular mass of 29 kDa. CLIC1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography. Introduction: Chloride channels are various group of proteins that control fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, regulation of intracellular pH, and maintenance of cell volume. CLIC1 is part of the p64 family and is localized to the cell nucleus. CLIC1 displays both nuclear and plasma membrane chloride ion channel activity. CLIC1 inserts into membranes and forms chloride ion channels. CLIC1 channel activity depends on the pH. CLIC1 membrane insertion is redox-regulated and happens under oxydizing conditions.
ncbi gi num :
567757607
ncbi acc num :
NP_001274522.1
ncbi gb acc num :
NM_001287593.1
uniprot acc num :
O00299
ncbi mol weight :
26,923 Da
ncbi summary :
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
uniprot summary :
CLIC1: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Belongs to the chloride channel CLIC family. Protein type: Membrane protein, integral; Channel, chloride. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: extracellular space; nuclear membrane; mitochondrion; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nuclear envelope; nucleus; vesicle; brush border. Molecular Function: chloride channel activity; protein binding; voltage-gated ion channel activity. Biological Process: positive regulation of osteoblast differentiation; regulation of mitochondrial membrane potential; regulation of cell cycle; chloride transport; signal transduction
size1 :
0.005 mg
price1 :
140 USD
size2 :
0.025 mg
price2 :
205
size3 :
1 mg
price3 :
2220
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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