Recombinant Human Arginase Type II | MyBioSource MBS143945 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Arginase Type II

catalog :

MBS143945

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143945

products type :

Recombinant Protein

products full name :

Recombinant Human Arginase Type II

products short name :

Arginase Type II

products name syn :

ARG2 Human; Arginase Type II Human Recombinant; Kidney Arginase; Non-Hepatic Arginase; EC 3.5.3.1; Arginase-2; Type II arginase; Kidney-type arginase; Arginase-2 mitochondrial

other names :

arginase-2, mitochondrial; Arginase-2, mitochondrial; arginase-2, mitochondrial; L-arginine amidinohydrolase; L-arginine ureahydrolase; arginase, type II; kidney arginase; kidney-type arginase; non-hepatic arginase; nonhepatic arginase; type II arginase; arginase 2; Kidney-type arginase; Non-hepatic arginase; Type II arginase

products gene name :

ARG2

other gene names :

ARG2; ARG2

uniprot entry name :

ARGI2_HUMAN

host :

E Coli

sequence length :

354

sequence :

MGSSHHHHHH SSGLVPRGSH MVHSVAVIGA PFSQGQKRKG VEHGPAAIRE AGLMKRLSSL GCHLKDFGDL SFTPVPKDDL YNNLIVNPRS VGLANQELAE VVSRAVSDGY SCVTLGGDHS LAIGTISGHA RHCPDLCVVW VDAHADINTP LTTSSGNLHG QPVSFLLREL QDKVPQLPGF SWIKPCISSA SIVYIGLRDV DPPEHFILKN YDIQYFSMRD IDRLGIQKVM ERTFDLLIGK RQRPIHLSFD IDAFDPTLAP ATFTPVVGGL TYREGMYIAE EIHNTGLLSA LDLVEVNPQL ATSEEEAKTT ANLAVDVIAS SFGQTREGGH IVYDQLPTPS SPDESENQAR VRI.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

0.5mg/ml solution containing 20mM Tris-HCl pH-8, & 10% glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

ENZYMES; Enzymes

products description :

Description: ARG2 Recombinant E Coli produced in E Coli is a single, non-glycosylated polypeptide chain containing 353 amino acids (23-354 a.a.) and having a molecular mass of 38.3 kDa. The ARG2 is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: ARG2 participates in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, ARG2 takes part in both male and female sexual arousal and therefore a potential target for the treatment of male and female sexual arousal disorders.

ncbi gi num :

4502215

ncbi acc num :

NP_001163.1

ncbi gb acc num :

NM_001172.3

uniprot acc num :

P78540

ncbi mol weight :

38,578 Da

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Polyamine Biosynthesis, Arginine = Ornithine = Putrescine Pathway (413403)

ncbi summary :

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

ARG2: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. Belongs to the arginase family. Protein type: EC 3.5.3.1; Amino Acid Metabolism - arginine and proline; Mitochondrial; Hydrolase. Chromosomal Location of Human Ortholog: 14q24.1. Cellular Component: mitochondrion; mitochondrial matrix. Molecular Function: metal ion binding; arginase activity. Biological Process: striated muscle contraction; arginine metabolic process; ureteric bud development; nitric oxide biosynthetic process; urea cycle

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage