Recombinant Human Acyl-Coenzyme A Dehydrogenase, C-4 to C-12 | MyBioSource MBS143938 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Acyl-Coenzyme A Dehydrogenase, C-4 to C-12

catalog :

MBS143938

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143938

products type :

Recombinant Protein

products full name :

Recombinant Human Acyl-Coenzyme A Dehydrogenase, C-4 to C-12

products short name :

Acyl-Coenzyme A Dehydrogenase

products name syn :

ACADM Human; Acyl-Coenzyme A Dehydrogenase, C-4 to C-12 Human Recombinant; ACADM; ACAD1; CAD; MCADH; MCAD; EC=1.3.99.3; Medium-chain specific acyl-CoA dehydrogenase; mitochondrial; FLJ18227; FLJ93013; FLJ99884

other names :

medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a; Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; medium-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; acyl-CoA dehydrogenase, C-4 to C-12 straight chain

products gene name :

ACADM

other gene names :

ACADM; ACADM; MCAD; ACAD1; MCADH; MCAD

uniprot entry name :

ACADM_HUMAN

host :

E Coli

sequence length :

421

sequence :

MGSSHHHHHH SSGLVPRGSH MKANRQREPG LGFSFEFTEQ QKEFQATARK FAREEIIPVA AEYDKTGEYP VPLIRRAWEL GLMNTHIPEN CGGLGLGTFD ACLISEELAY GCTGVQTAIE GNSLGQMPII IAGNDQQKKK YLGRMTEEPL MCAYCVTEPG AGSDVAGIKT KAEKKGDEYI INGQKMWITN GGKANWYFLL ARSDPDPKAP ANKAFTGFIV EADTPGIQIG RKELNMGQRC SDTRGIVFED VKVPKENVLI GDGAGFKVAM GAFDKTRPVV AAGAVGLAQR ALDEATKYAL ERKTFGKLLV EHQAISFMLA EMAMKVELAR MSYQRAAWEV DSGRRNTYYA SIAKAFAGDI ANQLATDAVQ ILGGNGFNTE YPVEKLMRDA KIYQIYEGTS QIQRLIVARE HIDKYKN.

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

The ACADM (0.5mg/ml) protein solution containing 20mM Tris-HCl pH-7.5, 0.1M NaCl & 20% glycerol. Sterile filtered clear solution.

storage stability :

ACADM Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

products categories :

ENZYMES; Enzymes; Dehydrogenase

products description :

Introduction: ACADM enzyme is essential for the degradation a certain group of fats called medium-chain fatty acids. ACADM is essential for converting specific fatty acids to energy, mainly during fasting periods. ACADM functions in mitochondria, the energy-producing centers within cells. ACADM is localized in the mitochondria of numerous tissue types, predominantly the liver. Description: ACADM Recombinant Human produced in E Coli is a single, non-glycosylated peptide chain contining 417 amino acids (26-421 a.a) and having molecular mass of 45.9 kDa. The ACADM is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

ncbi gi num :

4557231

ncbi acc num :

NP_000007.1

ncbi gb acc num :

NM_000016.5

uniprot acc num :

P11310

ncbi mol weight :

47,020 Da

ncbi pathways :

Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway (106127); Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway (106128); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Fatty Acid Beta Oxidation Pathway (198865); Fatty Acid Degradation Pathway (82935); Fatty Acid Degradation Pathway (296); Fatty Acid Metabolism Pathway (868084); Fatty Acid Metabolism Pathway (878045)

ncbi summary :

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid; Oxidoreductase; EC 1.3.8.7; Mitochondrial. Chromosomal Location of Human Ortholog: 1p31. Cellular Component: mitochondrion; mitochondrial matrix; axon; nucleus. Molecular Function: acyl-CoA dehydrogenase activity; identical protein binding; FAD binding. Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; medium-chain fatty acid catabolic process; cellular lipid metabolic process; medium-chain fatty acid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; carnitine biosynthetic process. Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage