catalog number :
MBS143931
products type :
Recombinant Protein
products full name :
Recombinant Canine Interleukin-3
products short name :
Interleukin-3
products name syn :
IL 3 Dog; Interleukin-3 Canine Recombinant; MCGF (Mast cell growth factor); Multi-CSF; HCGF; P-cell stimulation factor; IL-3; MGC79398; MGC79399
other names :
interleukin-3; Interleukin-3; interleukin-3; P-cell-stimulating factor; hematopoietic growth factor; mast cell growth factor; multipotential colony-stimulating factor; Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
products gene name :
k9 IL 3
other gene names :
IL3; IL3; IL-3; MCGF; IL-3; MCGF
uniprot entry name :
IL3_CANFA
sequence :
RPFSTDLPKQ YFTMINEIME MLNKSPSPSE EPLDSNEKET LLEDTLLRPN LDVFLNASSK FHKNGLLIWN NLKEFLPLLP TPTPRGEPIS IMENNWGDFQ RKLKKYLEAL DNFLNFKNKP.
purity :
Greater than 97.0% as determined by: (a) Analysis by HPLC. (b) Analysis by SDS-PAGE.
form :
Lyophilized from a concentrated (1mg/ml) solution in water containing 1X PBS pH7.4. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized IL3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL3 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized IL3 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose-dependant stimulation of TF-1 cells is < 0.2 ng/ml, corresponding to a Specific Activity of 5,000,000 IU/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Interleukin-3 Canine Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids and having a molecular mass of 14 kDa. The IL-3 is purified by proprietary chromatographic techniques. Introduction: IL3 is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
ncbi acc num :
NP_001013857.1
ncbi gb acc num :
NM_001013835.1
ncbi mol weight :
16,499 Da
ncbi pathways :
Apoptosis Pathway (84110); Apoptosis Pathway (470); Asthma Pathway (84166); Asthma Pathway (532); Cytokine-cytokine Receptor Interaction Pathway (84101); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198591); Fc Epsilon RI Signaling Pathway (84132); Fc Epsilon RI Signaling Pathway (493); Hematopoietic Cell Lineage Pathway (84128)