Recombinant Human Neuroblastoma RAS Viral Oncogene Homolog | MyBioSource MBS143929 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Neuroblastoma RAS Viral Oncogene Homolog

catalog :

MBS143929

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143929

products type :

Recombinant Protein

products full name :

Recombinant Human Neuroblastoma RAS Viral Oncogene Homolog

products short name :

Neuroblastoma RAS Viral Oncogene Homolog

products name syn :

NRAS Human; Neuroblastoma RAS Viral Oncogene Homolog Human Recombinant; GTPase NRas; HRAS1; ALPS4; N-ras; NRAS1; NS6; Transforming protein N-Ras

other names :

GTPase NRas; GTPase NRas; GTPase NRas; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog; neuroblastoma RAS viral (v-ras) oncogene homolog; Transforming protein N-Ras

products gene name :

NRAS

other gene names :

NRAS; NRAS; NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1; HRAS1

uniprot entry name :

RASN_HUMAN

host :

E Coli

sequence length :

189

sequence :

MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPC.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The NRAS protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5, 100mM NaCl, and 10% glycerol. Sterile Filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: NRAS Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 186 amino acids (1-186 a.a.) and having a molecular mass of 20.8kDa. The NRAS is purified by conventional chromatography. Introduction: NRAS binds GDP/GTP and has intrinsic GTPase activity. NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This transport is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. NRAS is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this NRAS gene result in juvenile myelomonocytic leukemia.

ncbi gi num :

4505451

ncbi acc num :

NP_002515.1

ncbi gb acc num :

NM_002524.4

uniprot acc num :

P01111

ncbi mol weight :

21,229 Da

ncbi pathways :

ARMS-mediated Activation Pathway (106466); Activation Of RAS In B Cells Pathway (576252); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688)

ncbi summary :

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

uniprot summary :

NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Oncoprotein; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1p13.2. Cellular Component: Golgi membrane; membrane; plasma membrane. Molecular Function: GTP binding; protein complex binding. Biological Process: regulation of long-term neuronal synaptic plasticity; epidermal growth factor receptor signaling pathway; negative regulation of skeletal muscle development; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; MAPKKK cascade; regulation of synaptic transmission, GABAergic; positive regulation of Rac protein signal transduction; negative regulation of cell differentiation; small GTPase mediated signal transduction; positive regulation of cell proliferation; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; striated muscle cell differentiation; visual learning; negative regulation of neuron apoptosis; blood coagulation; actin cytoskeleton organization and biogenesis; vascular endothelial growth factor receptor signaling pathway; leukocyte migration. Disease: Thyroid Carcinoma, Follicular; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Noonan Syndrome 6; Melanocytic Nevus Syndrome, Congenital; Colorectal Cancer; Melanosis, Neurocutaneous; Nevus, Epidermal

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage