protein

Recombinant Human T-cell Leukemia/Lymphoma 1A

MBS143923

0.01 mg

140 USD

Recombinant Protein

Recombinant Human T-cell Leukemia/Lymphoma 1A

T-cell Leukemia/Lymphoma 1A

TCL1A Human; T-cell Leukemia/Lymphoma 1A Human Recombinant; T-cell leukemia/lymphoma protein 1A; Protein p14 TCL1; Oncogene TCL-1; Oncogene TCL1; TCL1A; TCL1

T-cell leukemia/lymphoma protein 1A; T-cell leukemia/lymphoma protein 1A; T-cell leukemia/lymphoma protein 1A; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma 1A; Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1

TCL1A

TCL1A; TCL1A; TCL1; TCL1; Oncogene TCL1

TCL1A_HUMAN

E Coli

114

MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD.

Greater than 90.0% as determined by SDS-PAGE.

The TCL1A protein solution contains 50mM Tris-HCl buffer (pH7.5) and 10% glycerol. Sterile Filtered colorless solution.

TCL1A although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: TCL1A Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 114 amino acids (1-114 a.a.) and having a molecular mass of 13.4kDa.The TCL1A is purified by proprietary chromatographic techniques. Introduction: TCL1A (T-cell leukemia/lymphoma 1A) is a protein with a possible role in intracellular regulation of T cell signaling. TCL1A enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. TCL1A is restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. TCL1A is preferentially expressed early in T and B-lymphocyte differentiation. Chromosomal anomalies activating TCL1A are found in chronic T-cell leukemias (T-CLL). TCL1A enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. TCL1A promotes nuclear translocation of AKT1. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity, TCL1A can enhance the serine/threonine phosphorylation of major Akt signaling substrates, for example Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism.

148922879

NP_001092195.1

NM_001098725.1

P56279

13,460 Da

PI3K-Akt Signaling Pathway 692234!!PI3K-Akt Signaling Pathway 692979

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

0.01 mg

140 USD