Recombinant Feline Stromal Cell-Derived Factor-1 beta (CXCL12) | MyBioSource MBS143922 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Feline Stromal Cell-Derived Factor-1 beta (CXCL12)

catalog :

MBS143922

quantity :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143922

products type :

Recombinant Protein

products full name :

Recombinant Feline Stromal Cell-Derived Factor-1 beta (CXCL12)

products short name :

Feline Stromal Cell-Derived Factor-1 beta

products name syn :

SDF 1b Feline; Stromal Cell-Derived Factor-1 beta Feline Recombinant (CXCL12); SDF-1; CXCL12; Pre-B cell growth-stimulating factor; PBSF; hIRH; chemokine (C-X-C motif) ligand 12; SDF1; SDF1B; TPAR1; SCYB12; SDF-1b; TLSF-b; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; Thymic lymphoma cell-stimulating factor; TLSF

other names :

stromal cell-derived factor 1; Stromal cell-derived factor 1; stromal cell-derived factor 1; C-X-C motif chemokine 12; C-X-C motif chemokine 12

products gene name :

fSDF 1b

other gene names :

CXCL12; CXCL12; SDF-1; SDF1; SDF-1

uniprot entry name :

SDF1_FELCA

host :

E Coli

sequence length :

sequence :

KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRF KM.

purity :

Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein was lyophilized from a concentrated (1 mg/ml) sterile solution containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized SDF-1b although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL12 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized SDF-1b in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The specific activity as determined by its ability to chemoattract human peripheral T cells stimulated with IL-2 and PHA in a concentration range from 10-75 ng/ml corresponding to a Specific Activity of 13,334-100,000IU/mg.

products categories :

CHEMOKINES; Chemokines; SDF (CXCL12)

products description :

Description: Stromal Cell-Derived Factor-1 beta Feline Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 72 amino acids and having a molecular mass of 8526 Dalton. The SDF-1b is purified by proprietary chromatographic techniques. Introduction: SDF-1 (stromal cell-derived factor-1) is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12). It is produced in two forms, SDF-1?/CXCL12a and SDF-1?/CXCL12b, by alternate splicing of the same gene. Chemokines are characterized by the presence of four conserved cysteines, which form two disulfide bonds. The CXCL12 proteins belong to the group of CXC chemokines, whose initial pair of cysteines are separated by one intervening amino acid. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development. During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow. Mice which were knocked-out for CXCL12 gene were lethal before the birth or within just 1 hour of life. As another role, CXCL12a alters also the electrophysiology of neurons. CXCL12 was shown to be expressend in many tissues in mice (including brain, thymus, heart, lung, liver, kidney, spleen and bone marrow).The receptor for this chemokine is CXCR4, which was previously called fusin. This CXCL12-CXCR4 interaction used to be considered exclusive (unlike for other chemokines and their receptors), but recently it was suggested that CXCL12 is also bound by CXCR7 receptor. The gene for CXCL12 is located on human chromosome 10. In human and mouse both CXCL12 and CXCR4 show high identity of sequence: 99% and 90%, respectively.

ncbi gi num :

57619014

ncbi acc num :

NP_001009847.1

ncbi gb acc num :

NM_001009847.1

uniprot acc num :

O62657

ncbi mol weight :

10,018 Da

ncbi pathways :

Chemokine Signaling Pathway 741722!!Chemokine Signaling Pathway 96864!!Cytokine-cytokine Receptor Interaction Pathway 741721!!Cytokine-cytokine Receptor Interaction Pathway 460!!Intestinal Immune Network For IgA Production Pathway 741771!!Intestinal Immune Network For IgA Production Pathway 128670!!Leukocyte Transendothelial Migration Pathway 741768!!Leukocyte Transendothelial Migration Pathway 494!!NF-kappa B Signaling Pathway 741723!!Pathways In Cancer 741840

size :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage