protein

Recombinant Mouse Macrophage-Derived Chemokine (CCL22)

MBS143921

0.02 mg

205 USD

Recombinant Protein

Recombinant Mouse Macrophage-Derived Chemokine (CCL22)

Macrophage-Derived Chemokine

MDC Mouse; Macrophage-Derived Chemokine Mouse Recombinant (CCL22); C-C motif chemokine 22; Small-inducible cytokine A22; Macrophage-derived chemokine; MDC(1-69); Stimulated T-cell chemotactic protein 1; CC chemokine STCP-1; CCL22; MDC; SCYA22; ABCD-1; DC/B-CK; MGC34554; A-152E5.1; CC chemokine ABCD-1; Activated B and dendritic cell-derived; DCBCK

C-C motif chemokine 22; C-C motif chemokine 22; C-C motif chemokine 22; CC chemokine ABCD-1; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED); activated B and dendritic cell-derived; dendritic cell and B cell derived chemokine; small inducible cytokine subfamily A, member 22; small inducible cytokine subfamily A22; small-inducible cytokine A22; chemokine (C-C motif) ligand 22; Activated B and dendritic cell-derived; CC chemokine ABCD-1; Small-inducible cytokine A22

mMDC

Ccl22; Ccl22; MDC; DCBCK; ABCD-1; Scya22; Abcd1; Scya22

CCL22_MOUSE

E Coli

92

GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS.

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

CCL22 filtered (0.2 um) and lyophilized from a concentrated solution containing 20mM phosphate buffer & 150mM NaCl pH-7.4. Filtered White lyophilized (freeze-dried) powder.

Lyophilized CCL22 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL22 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized CCL22 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Determined by its ability to chemoattract human activated lymphocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

CHEMOKINES; Chemokines; MDC (CCL22)

Description: CCL22 Mouse Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7.8kDa. The Mouse CCL22 is purified by proprietary chromatographic techniques. Introduction: MDC (CCL22) is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4. CCL22 is vastly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. CCL22 is also found in the lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression of CCL22 can be seen in the lung and the spleen and very weak expression in the small intestine. In the lymph

6677879

NP_033163.1

NM_009137.2

O88430

10,302 Da

Chemokine Receptors Bind Chemokines Pathway 1110501!!Chemokine Signaling Pathway 99271!!Chemokine Signaling Pathway 672435!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 1110499!!Cytokine-cytokine Receptor Interaction Pathway 83248!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1111486!!Disease Pathway 1111319!!GPCR Ligand Binding Pathway 1110498

0.02 mg

205 USD