protein

Recombinant Human Growth Factor Receptor-Bound Protein 2

MBS143911

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Growth Factor Receptor-Bound Protein 2

Growth Factor Receptor-Bound Protein 2

GRB2 Human; Growth Factor Receptor-Bound Protein 2 Human Recombinant; ASH; Grb3-3; MST084; MSTP084; EGFRBP-GRB2; GRB2; Growth factor receptor-bound protein 2; Adapter protein GRB2; SH2/SH3 adapter GRB2; Protein Ash

growth factor receptor-bound protein 2 isoform 1; Growth factor receptor-bound protein 2; growth factor receptor-bound protein 2; HT027; SH2/SH3 adapter GRB2; abundant SRC homology; epidermal growth factor receptor-binding protein GRB2; growth factor receptor-bound protein 3; protein Ash; growth factor receptor-bound protein 2; Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2

GRB2

GRB2; GRB2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; ASH

GRB2_HUMAN

E Coli

217

Greater than 95.0% as determined by SDS-PAGE.

The GRB2 protein solution contains 20mM Tris-HCl, pH-8 and 30% glycerol. Sterile filtered colorless solution.

1 mg/ml

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: GRB2 produced in E Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-217 a.a.) and having a molecular mass of 27 kDa.GRB2 is expressed with a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques. Introduction: GRB2 is widely expressed and binds the EGFR and contains one SH2 domain and two SH3 domains which form a complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. GRB2 is related to the Sem5 gene of C.elegans, which is takes part in the signal transduction pathway. GRB2 is an adaptor protein that provides an important link between cell surface growth factor receptors and the Ras signaling pathway. Inhibition of GRB2 activity damages developmental processes in a variety of organisms and blocks transformation and proliferation of different cell types.

4504111

NP_002077.1

NM_002086.4

P62993

20,557 Da

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alpha6-Beta4 Integrin Signaling Pathway (198807); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Axon Guidance Pathway (105688); B Cell Receptor Signaling Pathway (198909)

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.005 mg

140 USD

0.025 mg

205

1 mg

2665